Postdoctoral Training in Cardiovascular Disease

描述(由申请者提供)：本申请申请为心血管疾病博士后培训计划的第三次竞争性续签申请资金。该计划旨在为以心脏病学、外科和儿科为基础的内科-科学家培训生提供机会，使其成为心血管研究的独立调查人员。学员将接触到不同的教职员工群体，从初级教员到全职教授，每个人都有充足的资金，都有出色的培训和出版记录。鼓励学员选择共同导师，以加强他们的多学科培训。教师导师将指导四个主要领域的研究培训：1)血管生物学，包括动脉粥样硬化、血管生成和干细胞；2)心肌细胞生物学，包括离子通道、药理学和组织和生物医学工程；3)免疫学和基因组学，包括移植和疾病标记物；4)翻译、结果和临床研究，包括心血管疾病的人口差异、获得心脏护理和选择性治疗的机会。重点是培养具有广泛的跨学科知识和独特技能的内科科学家，并对心血管生物学和生理学有很强的基础了解。该计划通常为期两年，根据受训者个人的选择，研究重点领域可能延长至三年。我们的临床培训项目包括外科、心胸外科、成人和儿科心脏病学、新生儿和儿科危重护理，候选人是从众多优秀申请者中挑选出来的，也可以直接申请参加培训项目。特别努力加强我们对妇女和少数民族的招募，部分是通过加入哈莱姆医院的外科住院医师计划。培训计划和核心部门有完善的心血管研讨会系列和期刊俱乐部，联合实验室会议和务虚会，旨在促进合作和跨学科研究。此外，培训计划本身还主办年度务虚会、研讨会和工作进展会议，以评估受训人员的进步。培训计划有一个有效的评估和反馈系统，以确保我们的研究员得到适当的培训。在整个项目期间和之后，学员将单独或通过学员发展副主任领导的指导项目，就研究和职业发展向学员提供建议。该计划旨在利用哥伦比亚大学现有的许多优势，包括欧文临床和翻译研究中心(CTSA)、梅尔曼公共卫生学院、基因组中心、生物信息学、组织和生物医学工程以及众多基础科学系和强大的临床计划，以及过去15年来该计划中内科科学家研究培训的既定记录。

DESCRIPTION (provided by applicant): This application requests funding for the third competitive renewal of a postdoctoral training program in Cardiovascular Diseases. The program is designed to provide opportunities for Cardiology, Surgical and Pediatrics-based physician-scientist trainees to become independent investigators in Cardiovascular research. Trainees will be exposed to a diverse group of faculty, ranging from junior faculty to full- professor, each well-funded, with outstanding training and publication records. Trainees are encouraged to choose co-mentors, to enhance their multi-disciplinary training. Faculty mentors will direct research training in four primary areas: 1) Vascular Biology including atherosclerosis, angiogenesis and stem cells; 2) Cardiomyocyte biology, including ion channels, pharmacology and tissue- and biomedical-engineering, 3) Immunology and Genomics, including transplantation and disease markers, and 4) Translational, Outcomes and Clinical Research, including population disparity in cardiovascular diseases, access to cardiac care and selective therapy. Strong emphasis is given to training physician-scientists with broadly- based, interdisciplinary knowledge and unique skill sets, with a strong fundamental understanding of cardiovascular biology and physiology. The usual duration of the program is two years and depending upon the individual trainees' selected area of research focus may be extended to three years. Candidates are selected from a very large pool of outstanding applicants to our clinical training programs in Surgery, Cardiothoracic Surgery, Adult and Pediatric Cardiology, Neonatology and Pediatric Critical Care, as well as through direct applications to the training program. Special efforts are undertaken to enhance our recruitment of woman and minorities, in part through affiliation with Harlem Hospital's Surgical Residency program. The training program and the core departments have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings and retreats that are designed to foster collaborations and interdisciplinary research. In addition, the training program itself sponsors an annual retreat, seminars and work-in-progress sessions to assess trainee progress. The training program has an efficient evaluation and feedback system to ensure appropriate training of our fellows. Throughout the program and afterwards, trainees are advised on research and career development, individually and through a mentoring program headed by an Associate Director for Trainee Development. The program is designed to take advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, Tissue and Biomedical Engineering and numerous basic science departments and strong clinical programs, as well as the established track record of research training of physician-scientists in this program for the past 15 years.