ESTABLISHMENT OF A NEW YORK REGIONAL ISLET ISOLATION FA*

建立纽约区域胰岛隔离 FA*

• 批准号: 6668543
• 负责人: MARK A HARDY
• 金额: $ 20万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6668543
• 关键词: apoptosis; biomedical equipment development; complementary DNA; cooperative study; cryopreservation; diabetes mellitus; diabetes mellitus therapy; flow cytometry; human subject; human therapy evaluation; microarray technology; pancreatic islet transplantation; pancreatic islets; patient oriented research; tissue resource /registry

Replacement of non-functional islet tissue with viable pancreatic islets by transplantation has proven to be effective using the Edmonton Protocol. Given the large population and the dedication of academic centers in the New York Metropolitan area to treat diabetes, our region clearly needs an islet isolation center for the purposes of investigational and clinical transplantation. We propose the establishment of the New York Regional Islet Resource Center to centralize islet isolation, purification, and distribution in a region serving more than 25 million people. While several institutions in this region already have Program Projects in Diabetes (Columbia University College of Physician and Surgeons, Mt. Sinai Medical School, Albert Einstein College of Medicine, and New York Weill-Cornell Medical Center), no programs other than Columbia/Weill-Cornell/New York-Presbyterian Hospital have developed expertise in human islet isolation. The IRC will support current and future protocols, taking advantage of clinical resources of the merged teaching hospital of New York-Presbyterian Hospital (NYPH) and the integration of the clinicians and scientists in the fields of surgery, pathology, medicine, and molecular biology. The Islet Resource Center, including a GMP grade Cell Therapy Facility, will address the issues and technical difficulties of isolating a sufficient islet mass, purifying and quantifying islets, developing improved markers of viability, function, quality control/assurance, banking and distribution according to proposed guidelines.

使用Edmonton方案，通过移植将无功能的胰岛组织替换为有活力的胰岛已被证明是有效的。鉴于纽约大都会地区人口众多，学术中心致力于治疗糖尿病，我们地区显然需要一个胰岛隔离中心，用于研究和临床移植。我们建议建立纽约地区小岛资源中心，将小岛的隔离、纯化和分发集中在一个服务于2500多万人口的地区。虽然这一地区的几个机构已经有糖尿病项目(哥伦比亚大学内科和外科医学院，Mt.西奈医学院、阿尔伯特·爱因斯坦医学院和纽约威尔康奈尔医学中心)，除了哥伦比亚大学/威尔康奈尔大学/纽约长老会医院外，没有其他项目开发出人类胰岛隔离方面的专业知识。IRC将利用纽约长老会医院(NYPH)合并后的教学医院的临床资源，以及外科、病理学、医学和分子生物学领域的临床医生和科学家的整合，支持当前和未来的协议。胰岛资源中心，包括GMP级细胞治疗设施，将根据拟议的指导方针，解决分离足够的胰岛质量、提纯和量化胰岛、开发更好的生存、功能、质量控制/保证、银行和分配标记的问题和技术困难。