Exploring the Diversity and Genetic Traits of the Beneficial Microbiota Genus Bifidobacterium

探索有益微生物群双歧杆菌属的多样性和遗传特征

• 批准号: 1786430
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1786430
• 关键词: Exploring; Diversity; Genetic; Traits; Beneficial

Within our gut we harbour a diverse collection of microbes (termed the microbiota) that are fundamental for our health. One of the dominant microbiota groups found during the first stages of life is Bifidobacterium, and presence of this genus in the gut has been linked to improved host immune defences. Due to their associated health benefits, there is significant need to explore the diversity of the bifidobacterial population at a global genetic level, determine the evolutionary scenario and also explore the influence of various genetic factors within the context of healthy host development. The goal of this PhD studentship is to study and understand bifidobacterial function through a mixture of `dry' (bioinformatics) and `wet' (lab-based) approaches using analysis of several hundred whole bifidobacterial genomes to uncover the genetic diversity of the genus, infer phylogenetic relationships and allow identification of potential health promoting genetic traits.

在我们的肠道内，我们拥有各种各样的微生物（称为微生物群），这些微生物对我们的健康至关重要。在生命的第一阶段发现的主要微生物群之一是双歧杆菌，肠道中该属的存在与宿主免疫防御的改善有关。由于其相关的健康益处，有必要在全球遗传水平上探索双歧杆菌种群的多样性，确定进化情景，并探索健康宿主发育背景下各种遗传因素的影响。这个博士研究生的目标是通过“干”（生物信息学）和“湿”（基于实验室）的方法的混合物，使用数百个完整的双歧杆菌细菌基因组的分析，以揭示属的遗传多样性，推断系统发育关系，并允许识别潜在的健康促进遗传性状，研究和了解双歧杆菌的功能。

项目成果

A novel bacteriocin produced by Bifidobacterium longum subsp. infantis has dual antimicrobial and immunomodulatory activity

一种由长双歧杆菌亚种产生的新型细菌素。

• DOI: 10.1101/2022.01.27.477972
• 发表时间: 2022
• 作者: Javvadi S

Bifidobacterium castoris strains isolated from wild mice show evidence of frequent host switching and diverse carbohydrate metabolism potential.

从野生小鼠中分离出来的双歧杆菌Castoris菌株显示出频繁开关和多种碳水化合物代谢潜力的证据。

• DOI: 10.1038/s43705-022-00102-x
• 发表时间: 2022-02-25
• 期刊: ISME COMMUNICATIONS
• 作者: Kujawska, Magdalena;Raulo, Aura;Millar, Molly;Warren, Fred;Baltrunaite, Laima;Knowles, Sarah C. L.;Hall, Lindsay J.
• 通讯作者: Hall, Lindsay J.