Conference on Genome and Hormones

描述(申请者提供)：APS会议主题为“基因组和 荷尔蒙：生理学性别差异的综合方法 定于2001年10月18日至20日在宾夕法尼亚州匹兹堡举行。几十年来， 基本生理系统的研究，扩展到临床试验 是从“正常体重70公斤男性”的研究结果中定义的。具有主动性 来自美国国立卫生研究院、妇女健康研究办公室和新兴领域的 药物遗传学，很明显，理解生理学上的差异 以及与男性和女性发病率相关的病理生理学 需要成为科学方法不可或缺的一部分。在过去十年中 多年来，荷尔蒙研究的新发现包括发现新的 激素受体，由其刺激、发育启动的细胞过程 合成和特异性雌激素受体调节剂(SERM)及其发展 缺乏性激素受体的动物。这些进展提供了新的 对性类固醇激素如何改变生理反应的见解 与Y染色体的存在无关。这些观察结果引发了 遗传性(X或Y染色体的存在)如何影响的问题 对性激素的生理反应。这样做的根本目的是 会议的目的是让遗传学、分子生物学、 综合生理学和临床医学解决遗传影响 对性激素的反应。会议的具体目标是：1) 召集一个国际公认的跨学科调查小组 探讨性激素从受体到受体的基本作用机制 细胞内过程以及这些基本机制如何影响 生理反应，包括疾病的表现；2)促进 青年科学家的参与，重点是妇女和 未被充分代表的少数群体，通过旅游奖励计划；以及3)利益 开展性别/性相关研究的新研究者和新学生 生理系统的各个方面。

DESCRIPTION (provided by applicant): The APS Conference on "Genome and Hormones: An Integrative Approach to Gender Differences in Physiology," is scheduled for October 18-20, 2001 in Pittsburgh, Pennsylvania. For decades, research of basic physiological systems, which extended into clinical trials were defined from results of studies of "normal 70 kg male." With initiatives from the NIH, Office of Women's Health Research, and emerging fields of pharmacogenetics, it is obvious that understanding differences in physiology and pathophysiology associated with incidence in disease in males and females needs to become an integral part of scientific approaches. Over the last ten years, new discoveries in hormone research have included discovery of new hormone receptors, cellular process initiated by their stimulation, development of synthetic and specific estrogen-receptor modulators (SERMS), and development of animals lacking sex steroid receptors. These advances have provided new insights into how sex steroid hormones alter physiological responses independent of the presence of Y chromosome. These observations have raised questions of how genetic sex (presence of the X or Y chromosome) influences physiological responses to sex hormones. The fundamental goal of this conference is to bring together experts in genetics, molecular biology, integrative physiology and clinical medicine to address genetic influences on responses to sex steroids. The Specific Aims of the conference are: 1) To convene an internationally recognized interdisciplinary group of investigators to discuss basic mechanisms of action of sex steroids from receptors to intracellular processes and how these basic mechanisms influence integrative physiological responses including presentation of disease; 2) to promote the participation of young scientists with an emphasis on women and underrepresented minorities, through a travel award program; and 3) to interest new investigators and students in pursuing research on gender/sex related aspects of physiological systems.