Conference on Genome and Hormones

基因组和激素会议

• 批准号: 6352351
• 负责人: Martin Frank
• 金额: $ 1.5万
• 依托单位: AMERICAN PHYSIOLOGICAL SOCIETY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352351
• 关键词: disease /disorder proneness /risk; epidemiology; functional /structural genomics; gender difference; genetic regulation; hormone regulation /control mechanism; meeting /conference /symposium; sex hormones; travel; women's health

DESCRIPTION (provided by applicant): The APS Conference on "Genome and Hormones: An Integrative Approach to Gender Differences in Physiology," is scheduled for October 18-20, 2001 in Pittsburgh, Pennsylvania. For decades, research of basic physiological systems, which extended into clinical trials were defined from results of studies of "normal 70 kg male." With initiatives from the NIH, Office of Women's Health Research, and emerging fields of pharmacogenetics, it is obvious that understanding differences in physiology and pathophysiology associated with incidence in disease in males and females needs to become an integral part of scientific approaches. Over the last ten years, new discoveries in hormone research have included discovery of new hormone receptors, cellular process initiated by their stimulation, development of synthetic and specific estrogen-receptor modulators (SERMS), and development of animals lacking sex steroid receptors. These advances have provided new insights into how sex steroid hormones alter physiological responses independent of the presence of Y chromosome. These observations have raised questions of how genetic sex (presence of the X or Y chromosome) influences physiological responses to sex hormones. The fundamental goal of this conference is to bring together experts in genetics, molecular biology, integrative physiology and clinical medicine to address genetic influences on responses to sex steroids. The Specific Aims of the conference are: 1) To convene an internationally recognized interdisciplinary group of investigators to discuss basic mechanisms of action of sex steroids from receptors to intracellular processes and how these basic mechanisms influence integrative physiological responses including presentation of disease; 2) to promote the participation of young scientists with an emphasis on women and underrepresented minorities, through a travel award program; and 3) to interest new investigators and students in pursuing research on gender/sex related aspects of physiological systems.

描述（由申请人提供）：关于“基因组和 激素：生理学性别差异的综合方法， 定于2001年10月18日至20日在宾夕法尼亚州匹兹堡举行。几十年来， 基础生理系统的研究，延伸到临床试验 根据“正常70 kg男性”的研究结果定义。“通过主动行动 来自美国国立卫生研究院，妇女健康研究办公室，以及新兴领域， 药物遗传学，很明显，了解生理学差异 与男性和女性疾病发生率相关的病理生理学 需要成为科学方法的组成部分。过去十 多年来，激素研究的新发现包括发现新的 激素受体，由其刺激启动的细胞过程，发育 合成和特异性雌激素受体调节剂（SERMS）， 缺乏性类固醇受体的动物。这些进步提供了新的 深入了解性类固醇激素如何改变生理反应 与Y染色体的存在无关。这些意见引起了 遗传性别（X或Y染色体的存在）如何影响 对性激素的生理反应这个项目的基本目标是 会议将汇集遗传学、分子生物学， 综合生理学和临床医学，以解决遗传对 对性类固醇的反应会议的具体目标是：（1） 召集一个国际公认的跨学科调查小组 从受体到受体， 细胞内过程以及这些基本机制如何影响整合 生理反应，包括疾病的表现; 2）促进 青年科学家的参与，重点是妇女， 代表性不足的少数民族，通过旅行奖励计划;和3）兴趣 新的调查员和学生进行性别/性相关的研究 生理系统的各个方面。