Conference on Physiological Bioenergetics: From Bench to Bedside

 描述(申请人提供)：在过去的2-30年里，很明显，线粒体执行多种功能来维持细胞内稳态，所有这些功能都与代谢和基因组程序密切相关，远远超出了简单地制造ATP的范围。在过去的5-10年里，新的尖端技术、新型的分子工具和线粒体靶向治疗技术的发展使得更准确和更深入地探讨线粒体的功能成为可能，并极大地改变了生理条件下的生物能量学的研究。我们对线粒体功能的调节机制及其对细胞内稳态的贡献的知识也在迅速扩大。然而，这些进展通常是在特定的病理学或器官系统的背景下取得的，并不总是被研究不同病理学的研究人员广泛认识到。此外，在将线粒体测量转化为人类研究方面，仍存在巨大的知识差距。“生理生物能量学--从工作台到床边”会议的目标是聚集在不同学科和不同病理学背景下研究生物能量学不同方面的专家，分享他们的最新发现，并讨论将“线粒体”领域推进到翻译和临床研究的策略。 拟议会议的具体目标是： 1.汇聚在不同学科和不同病理学背景下研究生物能量学不同方面的专家，分享他们的最新研究成果，并讨论策略 推动“线粒体学”领域进入翻译和临床研究。 2.为初级调查人员、研究生和博士后研究员提供一个以口头和海报演示的形式突出他们的研究的场所。 3.促进跨学科合作/对话，以了解TH线粒体在人类健康和疾病中的作用。 4.为代表人数不足的少数群体提供一个可以参与的论坛。 这次会议的主要吸引力将是它对跨学科和特定病理的基本线粒体机制的关注。这次会议将成为一座跨学科的桥梁， 允许在调查人员之间共享知识和建立合作，否则他们可能 被限制在他们研究的学科/病理学范围内。最终，这次会议的目标是推动线粒体的研究，特别是在临床研究领域，并促进跨学科的合作/对话，以了解线粒体在人类健康和疾病中的作用。

 DESCRIPTION (provided by applicant): In the last 2-3 decades, it has become apparent that mitochondria perform a multitude of functions to maintain cellular homeostasis, all of which are intimately linked to both metabolic and genomic programs extending well beyond simply making ATP. New cutting edge technology, novel molecular tools and mitochondrially targeted therapeutics developed in the past 5-10 years have made it possible to more accurately and deeply probe mitochondrial function and have dramatically altered the study of bioenergetics under physiological conditions. Our knowledge of the mechanisms by which mitochondrial function is regulated and its contribution to cellular homeostasis is also rapidly expanding. However, these advances are generally made in the context of a specific pathology or organ system and are not always widely recognized by investigators studying a different pathology. Further, a great gap in knowledge still exists in translating mitochondrial measurement to human studies. The goal of the "Physiological Bioenergetics-from Bench to Bedside" meeting is to bring together experts studying varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of "mitochondriology" into translational and clinical studies. The specific aims of the proposed conference are: 1. To bring together experts studying varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of "mitochondriology" into translational and clinical studies. 2. To provide a venue for junior investigators, graduate students and post-doctoral fellows to highlight their research in the form of oral and poster presentations. 3. To catalyze collaboration/conversation across disciplines to understand the role of th mitochondrion in human health and disease. 4. To provide a forum in which underrepresented minorities can participate. The major appeal of this conference will be its focus on basic mitochondrial mechanisms that cross disciplines and specific pathologies. This meeting will serve as a cross disciplinary bridge, allowing the sharing of knowledge and the establishment of collaborations among investigators who may otherwise be confined within the discipline/pathology they study. Ultimately, the goals of this meeting are to advance the study of mitochondria, particularly in the realm of clinical studies and to catalyze collaboration/conversation across disciplines to understand the role of the mitochondrion in human health and disease.