CONFERENCE--ALDOSTERONE AND ENaC:GENETICS TO PHYSIOLOGY

描述(由申请人提供)： APS关于“醛固酮和ENaC：从遗传学到生理学”的会议定于2003年9月10日至14日在加拿大班夫举行。该会议结合了两个具有重大科学重叠的相关领域：上皮钠通道(ENaC)和醛固酮的作用。醛固酮是钠重吸收中生理上最相关、研究最深入的刺激物。它激活肾脏和远端结肠中的ENaC和Na/K-ATPase。通过调节ENaC，醛固酮是控制全身钠平衡的主要激素，因此是控制血容量的主要激素，因此，在哺乳动物中，控制平均血压。因此，ENaC中醛固酮调节的异常对于理解高血压的潜在原因和相关的肾脏病理具有深远的意义。会议预计将吸引约300名科学家参与讨论阿米洛利敏感的钠离子通道的中心主题，它们的调节，以及它们在正常和病理生理情况下的参与，重点是醛固酮在调节这些过程中的作用。会议是每三年举行一次的非常成功的系列会议中的第四次，会议具有许多相同的特点，但由于科学进步、希望聘请年轻研究人员和促进性别平衡、与会者有更多时间进行海报研究陈述以及专门为会议参与者之间的非正式互动分配了时间而有所改变。与像实验生物学会议这样的大型、多社会会议不同，会议专门关注ENaC和醛固酮，特别强调ENaC和醛固酮调节在高血压以及肾和肺损伤的病理生理中可能发挥的作用。这次会议的目标是提供唯一一次与研究ENaC或醛固酮的关键群体调查人员的集中会议，以便两个天然联系的地区可以共享信息。在54名受邀演讲者和一名组织者中，四分之一是女性，45%是助理或副教授级别的人。为了增加受训人员或年轻调查人员的发言数量，5-6名海报主持人还将在例会上发表演讲。将有一个强大的学生奖励计划(12名获奖者将根据功绩来选择)。前三次会议的成功证明了其对科学界的必要性和价值。

DESCRIPTION (provided by applicant): The APS Conference on "Aldosterone and ENaC: from Genetics to Physiology" is scheduled for September 10-14, 2003 in Banff, Canada. The Conference combines two related fields with substantial scientific overlap: epithelial Na channels (ENaC) and the actions of aldosterone. Aldosterone is the most physiologically relevant and intensively studied stimulus of sodium reabsorption. It activates both ENaC and Na/K-ATPase in the kidney and distal colon. By regulating ENaC, aldosterone is the primary hormone that controls total body sodium balance and consequently is the major hormone that controls blood volume and, therefore, in mammals, controls mean blood pressure. Thus, abnormalities in aldosterone regulation of ENaC have profound implications for understanding the underlying causes of essential hypertension and related renal pathology. The Conference is expected to attract about 300 scientists to share in discussions about the central theme of amiloride-sensitive Na+ channels, their regulation, and their involvement in normal and pathophysiological situations, with an emphasis on the role of aldosterone in regulating these processes. The Conference is the fourth in a highly successful series held at 3 year intervals and has many of the same features, modified however by scientific progress, the desire to feature younger investigators and promote gender balance, by more time for attendee poster research presentations, and by specifically allocated time for informal interactions among Conference participants. In contrast to large, multi-society meetings like the Experimental Biology meeting, there is an exclusive focus on ENaC and aldosterone with particular emphasis on the role that ENaC and aldosterone regulation may play in the pathophysiology of high blood pressure and kidney and lung injury. This conference has the goal of providing the only focused meeting with critical mass of investigators examining ENaC or aldosterone so that two naturally allied areas can share information. One quarter of the 54 invited speakers and one of the organizers are female, and 45% are at the Assistant or Associate professor level. To increase the number of presentations by trainees or young investigators, 5-6 poster presenters will also present talks in the regular sessions. There will be a strong student awards program (12 awardees to be selected on the basis of merit). The success of three preceding meetings attests to its need and value to the scientific community.