Conference on Aldosterone and ENaC

醛固酮和 ENaC 会议

• 批准号: 8202298
• 负责人: Martin Frank
• 金额: $ 0.8万
• 依托单位: AMERICAN PHYSIOLOGICAL SOCIETY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8202298
• 关键词: Adrenal Cortex; Aldosterone; American; Area; Basic Science; Blood Pressure; Blood Vessels; California; Cardiac; Cardiac Volume; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Clinical; Clinical Research; Collaborations; Colon; Communication; Communities; Congestive Heart Failure; Development; Diffuse; Disease; Distal; Electrolytes; Endocrine; Environment; Epithelial; Epithelium; Europe; Exposure to; Extracellular Fluid; Faculty; Family; Fibrosis; Functional disorder; Future; Gender; Goals; Health; Hormones; Human; Human Biology; Hypertension; International; Ion Channel; Ion Channel Protein; Ion Transport; Kidney; Kidney Diseases; Ligands; Link; Measures; Mechanics; Mind; Molecular; Mucociliary Clearance; Na(+)-K(+)-Exchanging ATPase; Nephrons; Nervous System Physiology; Neuraxis; North America; Organ; Organism; Participant; Physiological; Population; Process; Production; Pulmonary alveolar structure; Regulation; Renal function; Research; Research Personnel; Role; San Francisco; Schedule; Scientist; Series; Societies; Sodium Channel; Students; Thinking; Time; Tissues; Translational Research; Universities; Work; absorption; airway surface liquid; authority; blood pressure regulation; epithelial Na+ channel; graduate student; innovation; interest; lectures; meetings; member; outreach; posters; programs; research and development; steroid hormone; symposium

DESCRIPTION (provided by applicant): The purpose of this proposal is to seek support for the APS Conference entitled "7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels: Molecular Mechanisms and Pathophysiology" that is scheduled to take place at the historic and secluded Asilomar Conference Grounds located in Pacific Grove, California. A major goal of this conference will be to bring together clinical and basic researchers from all over the globe with an interest in ENaC (and related transporters) and aldosterone, particularly as they pertain to renal and cardiovascular disorders, including hypertension. Hence, the scientific themes are a blend of clinical, basic and translational research, which allow a diverse community to break down obstacles to communication and engage in crosstalk, which would not otherwise be possible. By focusing on ENaC and aldosterone in the context of the renal and cardiovascular systems, the meeting provides a window into basic and clinical questions, which are fundamental to human biology in health and disease. The conference program combines presentations from leading authorities with presentations from young investigators pursuing research on ENaC and aldosterone. Ample time for poster sessions will allow for in-depth discussions, and special featured poster sessions will highlight ongoing research of students, fellows, and young scientists. The objectives of the conference are: Aim 1) to bring together world leaders in clinical, translational and basic research in aldosterone and ENaC, and related areas for a multi-day intensive retreat to present and discuss the latest research in the field; Aim 2) to have a large representation of junior researchers, from graduate students (and exceptional undergraduates) through postdoctoral researchers to junior faculty; these junior participants will present their new work, and also benefit from exposure to the research and thinking of leaders in the field; a new innovation in for the 7th International Symposium will be a series of overview lectures for each thematic area, given by leaders in the field. Aim 3) create an environment in which clinical and basic scientists in the field can exchange ideas, and ideally initiate collaborations, which would otherwise not occur; Aim 4) engender interest in aldosterone-ENaC research in junior investigators, which will influence research directions, and help move research in the field forward; Aim 5) generate gender and ethnic diversity through outreach and proactive recruitment of underrepresented populations. PUBLIC HEALTH RELEVANCE: The International Symposium on Aldosterone and ENaC is an international meeting, which has been held every 3-4 years, alternating between North America and Europe for almost 20 years. These meetings have been attended by clinical and basic researchers from all over the globe with an interest in ENaC (and related transporters) and aldosterone, particularly as they pertain to renal and cardiovascular disorders, including hypertension. Hence, the scientific themes are a blend of clinical, basic and translational research, which allow a diverse community to break down obstacles to communication and engage in crosstalk, which would not otherwise be possible. By focusing on ENaC and aldosterone in the context of the renal and cardiovascular systems, the meeting provides a window into basic and clinical questions, which are fundamental to human biology in health and disease. The purpose of this proposal is to seek support for a scientific research conference, entitled "Aldosterone, ENaC and Cardiovascular Disease" scheduled for September 18-22, 2011 at the Asilomar Conference Center in Pacific Grove, CA. The conference is managed by the American Physiological Society (APS) and organized by Drs. Thomas Kleyman, University of Pittsburgh, and Dr. David Pearce, University of California, San Francisco. The aim of the meeting is to gather leaders in the field to discuss their ongoing translational research and issues related to the topic of ENaC (and related transporters) and aldosterone, particularly as they pertain to renal and cardiovascular disorders, including hypertension, to outline the future direction of that work, and to establish collaborative relationships to accomplish this future research.

描述（由申请人提供）：该提案的目的是寻求对APS会议的支持，题为“第七届国际醛固酮国际研讨会和ENAC/Degenerin ION渠道家族：分子机制和病理生理学”，原定于历史悠久的Asiloded aslud aslud aslud aslud assilomar会议场地，位于加利福尼亚州的Pacific Grove。本次会议的主要目标是将来自全球的临床和基础研究人员汇集到对ENAC（及相关转运蛋白）和醛固酮感兴趣的临床和基础研究人员，尤其是与肾脏和心血管疾病有关，包括高血压。因此，科学主题是临床，基础和转化研究的融合，这使一个多样化的社区能够打破沟通和参与串扰的障碍，否则这是不可能的。通过在肾脏和心血管系统的背景下专注于ENAC和醛固酮，会议为基本和临床问题提供了一个窗口，这些问题是健康和疾病中人类生物学基础的基本问题。会议计划将领先当局的演讲与年轻调查人员的演讲相结合，从事有关ENAC和醛固酮的研究。大量的海报会议时间将允许进行深入讨论，而特殊的海报会议将突出对学生，研究员和年轻科学家进行的正在进行的研究。 会议的目标是：目标1）将醛固酮和ENAC的临床，转化和基础研究中的世界领导者汇集在一起​​，以及相关领域的多天密集度务虚会，以介绍和讨论该领域的最新研究； 目标2）从研究生（和杰出的大学生）到博士后研究人员到初级教师，从研究生（和杰出的本科生）到初级研究人员的大量代表；这些初级参与者将展示他们的新作品，并受益于该领域领导者的研究和思考。第七届国际研讨会的一项新创新将是该领域领导者给出的每个主题领域的一系列概述讲座。 目标3）创造一个环境，在该环境中，该领域的临床和基础科学家可以交换思想，并理想地启动合作，否则就不会发生； 目标4）在初级研究人员中引起对醛固酮-ENAC研究的兴趣，这将影响研究方向，并有助于将领域的研究向前发展； 目的5）通过宣传和积极招募代表性不足的人群来产生性别和种族多样性。 公共卫生相关性：国际醛固酮和ENAC的研讨会是一次国际会议，每3 - 4年一次举行一次，在北美和欧洲之间交替近20年。来自全球各地的临床和基础研究人员参加了这些会议，对ENAC（及相关转运蛋白）和醛固酮感兴趣，尤其是与肾脏和心血管疾病有关，包括高血压。因此，科学主题是临床，基础和转化研究的融合，这使一个多样化的社区能够打破沟通和参与串扰的障碍，否则这是不可能的。通过在肾脏和心血管系统的背景下专注于ENAC和醛固酮，会议为基本和临床问题提供了一个窗口，这些问题是健康和疾病中人类生物学基础的基本问题。该提案的目的是寻求支持科学研究会议，题为“醛固酮，ENAC和心血管疾病”，计划于2011年9月18日至22日在加利福尼亚州太平洋格罗夫的Asilomar会议中心举行。该会议由美国生理学会（APS）管理，并由博士组织。匹兹堡大学的托马斯·克莱曼（Thomas Kleyman）和加利福尼亚大学旧金山分校的戴维·皮尔斯（David Pearce）博士。会议的目的是吸引该领域的领导者，讨论他们正在进行的转化研究以及与ENAC（及相关转运蛋白）和醛固酮有关的问题，尤其是与肾脏和心血管疾病有关，包括高血压，包括高血压，以概述该工作的未来方向，并建立协作关系以实现这一未来研究。