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Workshop on DNA Repair and related DNA transactions

DNA修复及相关DNA交易研讨会

基本信息

批准号：
6419905
负责人：
JAMES M. FORD
金额：
$ 0.9万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-05 至 2002-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6419905
关键词：
DNA repair aging carcinogenesis workshop

项目摘要

DESCRIPTION (Provided by applicant): Funds are requested to enable scientists to participate in the Workshop on DNA Repair and Related DNA Transactions to be held at the Stanford Sierra Camp Conference Center, Fallen Leaf Lake, CA, Oct. 4 - Oct. 7, 2001. The selected speakers are current leaders in the fields of DNA repair and related cellular processes. Besides providing a forum for these experts to present their most recent results and ideas, the conference will facilitate wide-ranging interactions among all attendees through Plenary Discussion Sessions and focused discussion groups. Selected participants will be given the opportunity to highlight their research results in short presentations. To stimulate debate following the plenary talks. there will also be an opportunity for a limited number of poster presentations. The Conference's attendance is limited to 100 people. The participants will represent a well- balanced mix of individuals ranging from leaders in DNA repair, younger scientists new to the field, and experts in areas of research that link DNA repair to other cellular functions, e.g. replication, transcription and recombination. A concerted attempt will be made to include qualified minority scientists in the conference. The general focus of the Conference will reflect the explosive growth of the DNA repair field and the exciting, current data that emphasize the importance of DNA repair in human health, aging and carcinogenesis. The first session will feature a keynote address by Dr. Philip C. Hanawalt and a special lecture by Dr. Richard Setlow. The following plenary sessions and discussion groups will define areas in which exciting new information is emerging but in which experts may disagree. The session topics include: DNA repair enzyme structure, Recognition of damaged DNA and initiation of global genomic repair, Chromatin structure and localization of DNA repair, Inducible responses and cell cycle checkpoints, Base excision repair, Transcription-coupled repair. Overlap between DNA repair pathways, Transcription of damaged DNA, Translesion DNA synthesis, Recombination, signaling and other DNA transactions, DNA repair deficiency in human genetic disease, Repair gene polymorphisms, Role of endogenous DNA damage in human disease and aging, Genetic toxicology and cancer. The focused discussion groups will permit short presentations and exchange of ideas that will extend the themes introduced during plenary sessions. In summary, this Conference will examine DNA repair as a key component in the genomic surveillance that is so crucial to the overall integrity and function of cells and organisms. Recent discoveries have catapulted DNA repair into a pivotal position in fundamental research in the fields of oncology, aging, environmental health,and developmental biology. We hope to highlight the most promising and exciting avenues of research in robust discussions at this conference. The outcome and summary of the discussions are to be submitted to the journal, Cancer Research, for publication following the conference.

描述(由申请人提供)：申请资金以使科学家能够参加DNA研讨会修复和相关DNA交易将在斯坦福塞拉营地举行会议中心，加利福尼亚州落叶湖，2001年10月4日至10月7日。选定的演讲者是DNA修复和相关细胞领域的当前领先者流程。除了为这些专家提供一个论坛，让他们展示他们最近期的成果和想法，将促进会议的广泛开展所有与会者之间通过全体讨论会议和集中讨论小组。选定的参与者将获得有机会在简短的演讲中突出他们的研究成果。至在全体会谈之后激发辩论。还将有一个有机会进行有限数量的海报展示。本会议的出席人数限制为100人。参赛者将代表一个良好的- 平衡的个人组合，从DNA修复领域的领导者，到更年轻的新进入该领域的科学家和研究领域的专家将DNA 修复其他细胞功能，如复制、转录和重组。将作出协调一致的努力，将符合条件的少数族裔包括在内参加会议的科学家们。会议的总体重点将反映出 DNA修复领域和令人兴奋的最新数据强调了 DNA修复在人类健康、衰老和癌症发生中的作用。第一次会议将以菲利普·C·哈纳瓦特博士的主旨演讲和特别演讲为特色理查德·塞特洛博士写的。以下全体会议和讨论小组将定义哪些领域正在出现令人兴奋的新信息，但在哪些领域专家们可能会有不同意见。课程主题包括：DNA修复酶结构，识别受损的DNA和启动全球基因组修复，染色质结构和DNA修复的定位、诱导反应和细胞周期检查点，碱基切除修复，转录偶联修复。 DNA修复途径、受损DNA转录、转损之间的重叠 DNA合成、重组、信号和其他DNA交易、DNA修复在人类遗传性疾病中的缺陷，修复基因的多态性，作用内源性DNA损伤与人类疾病和衰老、遗传毒理学和癌症。重点讨论小组将允许简短的演讲和交流意见，扩展全体会议期间介绍的主题会话。总而言之，本次会议将把DNA修复作为一项关键基因组监测中的一部分，这对整个细胞和生物体的完整性和功能。最近的发现已经 DNA修复在基础研究中的关键地位肿瘤学、老年学、环境健康和发育生物学领域。我们希望突出最有前途和最令人兴奋的研究途径在这次会议上的热烈讨论。会议的结果和总结讨论将提交给《癌症研究》杂志，供会议结束后出版。