Workshop on DNA Repair and related DNA transactions

描述（由申请人提供）： 要求提供资金，使科学家能够参加DNA讲习班 修复和相关的DNA交易将在斯坦福大学塞拉营地举行 会议中心，落叶湖，加利福尼亚州，2001年10月4日至7日。 所选 演讲者是目前DNA修复和相关细胞领域的领导者。 流程. 除了为这些专家提供一个论坛， 最近的成果和想法，会议将促进广泛的 所有与会者通过全体讨论会进行互动， 集中讨论组。 获选参加者将获发 有机会在简短的演讲中突出他们的研究成果。 到 在全体会议之后进行辩论。也将有一个 提供有限的海报展示机会。 裁谈会 参观人数限制在100人以内。 参与者将代表一个良好的- 从DNA修复的领导者，年轻人， 科学家新的领域，和专家的研究领域，连接DNA 修复其他细胞功能，例如复制、转录和 重组 将作出协调一致的努力， 科学家在会议上。 会议的总体重点将反映出 DNA修复领域和令人兴奋的，当前的数据，强调了重要性 DNA修复在人类健康、衰老和癌症发生中的作用。 第一届会议 将由菲利普·C博士发表主题演讲。哈纳沃特和一个特别的讲座 理查德·塞特洛博士 下列全体会议和讨论小组 将定义令人兴奋的新信息正在出现的领域， 专家们可能不同意。 会议主题包括：DNA修复酶 结构，识别受损的DNA和启动整体基因组修复， 染色质结构和DNA修复的定位，诱导反应和 细胞周期检查点，碱基切除修复，转录偶联修复。 DNA修复途径之间的重叠，受损DNA的转录，转录 DNA合成、纯化、信号传导和其他DNA交易、DNA修复 人类遗传病缺陷，修复基因多态性，作用 人类疾病和衰老中的内源性DNA损伤，遗传毒理学和 癌 重点讨论小组将允许简短的发言， 交流意见，扩大全体会议期间提出的主题 sessions. 总之，本次会议将研究DNA修复作为一个关键， 基因组监控中的一个组成部分， 细胞和生物体的完整性和功能。 最近的发现 使DNA修复在基础研究中处于关键地位， 肿瘤学、衰老、环境健康和发育生物学领域。 我们 希望突出最有前途和令人兴奋的研究途径， 在这次会议上进行了热烈的讨论。 会议结果和摘要 讨论将提交给《癌症研究》杂志， 会议后出版。

DESCRIPTION (Provided by applicant): Funds are requested to enable scientists to participate in the Workshop on DNA Repair and Related DNA Transactions to be held at the Stanford Sierra Camp Conference Center, Fallen Leaf Lake, CA, Oct. 4 - Oct. 7, 2001. The selected speakers are current leaders in the fields of DNA repair and related cellular processes. Besides providing a forum for these experts to present their most recent results and ideas, the conference will facilitate wide-ranging interactions among all attendees through Plenary Discussion Sessions and focused discussion groups. Selected participants will be given the opportunity to highlight their research results in short presentations. To stimulate debate following the plenary talks. there will also be an opportunity for a limited number of poster presentations. The Conference's attendance is limited to 100 people. The participants will represent a well- balanced mix of individuals ranging from leaders in DNA repair, younger scientists new to the field, and experts in areas of research that link DNA repair to other cellular functions, e.g. replication, transcription and recombination. A concerted attempt will be made to include qualified minority scientists in the conference. The general focus of the Conference will reflect the explosive growth of the DNA repair field and the exciting, current data that emphasize the importance of DNA repair in human health, aging and carcinogenesis. The first session will feature a keynote address by Dr. Philip C. Hanawalt and a special lecture by Dr. Richard Setlow. The following plenary sessions and discussion groups will define areas in which exciting new information is emerging but in which experts may disagree. The session topics include: DNA repair enzyme structure, Recognition of damaged DNA and initiation of global genomic repair, Chromatin structure and localization of DNA repair, Inducible responses and cell cycle checkpoints, Base excision repair, Transcription-coupled repair. Overlap between DNA repair pathways, Transcription of damaged DNA, Translesion DNA synthesis, Recombination, signaling and other DNA transactions, DNA repair deficiency in human genetic disease, Repair gene polymorphisms, Role of endogenous DNA damage in human disease and aging, Genetic toxicology and cancer. The focused discussion groups will permit short presentations and exchange of ideas that will extend the themes introduced during plenary sessions. In summary, this Conference will examine DNA repair as a key component in the genomic surveillance that is so crucial to the overall integrity and function of cells and organisms. Recent discoveries have catapulted DNA repair into a pivotal position in fundamental research in the fields of oncology, aging, environmental health,and developmental biology. We hope to highlight the most promising and exciting avenues of research in robust discussions at this conference. The outcome and summary of the discussions are to be submitted to the journal, Cancer Research, for publication following the conference.