The role of Klotho, anti-aging molecule, in chronic gastritis and gastric carcinogenesis

klotho基因最初被鉴定为衰老抑制基因。 我们调查Klotho是否参与胃病的病理生理学。 研究1：胃溃疡与幽门螺杆菌（Hp）感染有关。 在胃溃疡愈合过程中，Klotho在溃疡边缘的胃上皮细胞中的mRNA表达与正常胃组织相比减少。 重组Klotho的施用加速胃溃疡愈合。（研究二）探讨了TLR 9在H.幽门螺杆菌诱导的小鼠胃炎。 我们的研究结果表明，TLR 9信号在抑制H。通过下调IFN-α 1调节的TNF-α，幽门诱导的早期胃粘膜炎症 （研究3）与未感染的小鼠相比，在Hp感染的小鼠中Klotho的mRNA表达下调，这表明促进了胃的萎缩和癌变。

The klotho gene was originally identified as an aging suppressor gene. We investigated whether Klotho is involved in pathophysiology in the stomach diseases. (Study 1) Gastric ulcer is associated with Helicobacter pylori (Hp) infection. During gastric ulcer healing, expression of mRNA for Klotho in gastric epithelial cells at the ulcer margin was reduced compared with normal gastric tissue. Administration of recombinant Klotho accelerated gastric ulcer healing. (Study 2) We investigated the expression and role of TLR9 in H. pylori-induced gastritis in mice. Our findings suggest that TLR9 signaling plays important roles in the suppression of H. pylori-induced gastric mucosal inflammation in the early phase via downregulation of TNF-alpha modulated by IFN-alpha1. (Study 3) Expression of mRNA for Klotho was downregulated in Hp-infected mice compared uninfected mice, suggesting the promotion of atrophy and carcinogenesis of the stomach .