The role of Klotho, anti-aging molecule, in chronic gastritis and gastric carcinogenesis

klotho基因最初被确定为一种衰老抑制基因。我们探讨Klotho是否参与胃病的病理生理过程。（研究1）胃溃疡与幽门螺杆菌（Hp）感染有关。在胃溃疡愈合过程中，与正常胃组织相比，溃疡边缘胃上皮细胞中Klotho mRNA的表达减少。重组Klotho可加速胃溃疡愈合。（研究2）我们研究了TLR9在幽门螺杆菌诱导的小鼠胃炎中的表达及其作用。我们的研究结果表明，TLR9信号通过下调IFN-alpha1调节的tnf - α，在早期抑制幽门螺杆菌诱导的胃粘膜炎症中发挥重要作用。（研究3）hp感染小鼠与未感染小鼠相比，Klotho mRNA表达下调，提示其促进胃萎缩和癌变。

The klotho gene was originally identified as an aging suppressor gene. We investigated whether Klotho is involved in pathophysiology in the stomach diseases. (Study 1) Gastric ulcer is associated with Helicobacter pylori (Hp) infection. During gastric ulcer healing, expression of mRNA for Klotho in gastric epithelial cells at the ulcer margin was reduced compared with normal gastric tissue. Administration of recombinant Klotho accelerated gastric ulcer healing. (Study 2) We investigated the expression and role of TLR9 in H. pylori-induced gastritis in mice. Our findings suggest that TLR9 signaling plays important roles in the suppression of H. pylori-induced gastric mucosal inflammation in the early phase via downregulation of TNF-alpha modulated by IFN-alpha1. (Study 3) Expression of mRNA for Klotho was downregulated in Hp-infected mice compared uninfected mice, suggesting the promotion of atrophy and carcinogenesis of the stomach .