CONFERENCE ON FIBRONECTIN/INTEGRINS RELATED MOLECULES

描述：（改编自申请人摘要）细胞相互作用的研究 与细胞外基质的关系在过去的十年里急剧增长。纤连蛋白具有 被 原型 细胞外基质分子 大部分 本 自1982年以来，这一直是戈登会议的主要焦点。 20世纪80年代中期发现整合素作为纤连蛋白的受体， 细胞外基质的其他成分扩大了 会议 在过去的五年里，人们逐渐认识到整合素 功能和特异性由质膜和胞质调节 分子伙伴进一步扩大了会议的范围。在一起， 纤连蛋白、整联蛋白及其 绑定伙伴控制许多基本的 生物过程包括细胞粘附、细胞形状、细胞的组织结构、细胞的分化和分化。 细胞骨架和细胞外基质，细胞运动， 形态发生和组织相互作用，免疫细胞运输， 细胞活化状态和对生长因子的反应、诱导和消退 炎症、止血和伤口修复。以下重要新闻 在过去四年中，我们的见解有所发展。首先，有一个更好的 了解参与调节的分子机制， 整合素的活化状态，对它们结合配体和 发射信号。 第二，更好地了解自然， 调节在粘附位点组装的信号复合物，包括 细胞骨架成分，受体和非受体酪氨酸激酶，以及其他 信号级联的元素。第三，新的配体家族，包括TGF- β，神经元和免疫粘附分子，和去整合素，以及新的 物理相关的分子家族，包括四跨膜蛋白，小窝蛋白， 和多个胞质伴侣拓宽了 整合素功能。 第四，通过确定整合素的核心作用， 各种生理和病理状态下的功能和功能障碍， 这些分子现在更适合于治疗用途。 本申请中概述的会议旨在传达这些 令人兴奋的新发展和激励与会者之间的讨论， 不同的学科。这种异花授粉是 激发了新的洞察力和信息浪潮。

DESCRIPTION: (Adapted from Applicant s Abstract) Research on cell interactions with extracellular matrix has exploded during the past decade. Fibronectin has been the prototype extracellular matrix molecule for much of this investigation and has been a major focus of this Gordon Conference since 1982. The discovery of integrins in the mid-1980s as receptors for fibronectin and other constituents of the extracellular matrix expanded the scope of the conference. The emerging understanding over the last five years that integrin function and specificity is regulated by plasma membrane and cytosolic molecular partners has further expanded the scope of the conference. Together, fibronectin, integrins, and their binding partners control many basic biological processes including cell adhesion, cell shape, organization of the cytoskeleton and the extracellular matrix, cell motility, regulation of morphogenesis and tissue interactions, immune cell trafficking, regulation of cell activation state and response to growth factors, induction and resolution of inflammation, hemostasis, and wound repair. The following important new insights have developed in the last four years. First, there is a better understanding of the molecular mechanisms involved in regulation of the activation state of integrins, critical to their ability to bind ligand and transduce signals. Second, there is better insight into the nature and regulation of signaling complexes assembled at adhesion sites, including cytoskeletal components, receptor and non-receptor tyrosine kinases, and other elements of signaling cascades. Third, new families of ligands, including TGF- beta, neuronal and immune adhesion molecules, and disintegrins, as well as new families of physically associated molecules including tetraspanins, caveolin, and multiple cytosolic partners have broadened the context within which integrins function. Fourth, by identifying a central role for integrin function and dysfunction in a variety of physiologic and pathologic states, these molecules are now more appropriate for therapeutic use. The conference outlined in this application is directed at communicating these exciting new developments and stimulating discussion among participants from different disciplines. This cross-pollination is a most effective way of stimulating new waves of insight and information.