MEMBRANE PROTEIN STRUCTURE FUNCTION RELATIONSHIPS

膜蛋白结构功能关系

• 批准号: 6223590
• 负责人: Howard Ronald KABACK
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6223590
• 关键词: meeting /conference /symposium; membrane proteins; protein structure function; structural biology; travel

DESCRIPTION (taken from the application) Of the genomes sequenced thus far, about 30 percent of the gene products are predicted to be polytopic transmembrane proteins. These hydrophobic proteins catalyze a multitude of essential functions, from oxidative phosphorylation and electron transfer to transport of molecules into and out of cells and intracellular organelles to signal transduction across membranes, and many are important with regard to human disease. Although advances in molecular biology and biochemistry over the past 15 years have led to the characterization, purification and modification of this class of proteins, only a handful of these proteins have been crystallized in a form that allows structure determination at atomic resolution, which is essential for understanding mechanism of action. Furthermore, many membrane proteins require conformation flexibility in order to function, making it imperative to obtain dynamic information as well in order to fully understand function. Thus, a major problem in this area is the difficulty inherent in obtaining structural information at a relevant level of resolution.The purpose of this symposium is to bring together a wide range of key investigators from a diversity of disciplines studying structure/function relationships at the molecular level in polytopic membrane proteins involved in a variety of functions from as many different perspectives as possible. No other such all encompassing conferences specific to this problem have ever been held and it is expected that by bringing such individuals together, discussions will focus the field on the importance of high resolution structure-function studies in order to understand this important class of biological molecules. Thus, this Symposium will cover the remarkable developments that have occurred in the area over the past 30 years, as well as what portends for the future. Due to the fact that this symposium will be so unique it is critical to the careers of graduate students and postdoctoral follows interested in furthering the understanding of these advancing studies. To this end, we have encouraged the session chairs to invite younger investigators whenever possible. In addition, a workshop on "Emerging Techniques" and a poster session are included in the program. We also intend to actively encourage graduate students and postdoctoral fellows to attend the meeting and participate in these sessions.

描述(取自应用程序) 到目前为止，在测序的基因组中，大约30%的基因产物是 预测是多面体跨膜蛋白。这些疏水蛋白质 催化许多基本功能，从氧化磷酸化和 电子转移到分子进出细胞的运输和 细胞内细胞器跨膜信号转导，其中许多是 对人类疾病来说很重要。尽管分子生物学的进展 在过去的15年里，生物化学导致了这种表征， 这类蛋白质的纯化和修饰，只有少数 这些蛋白质已经结晶成一种允许结构的形式 原子分辨率的测定，这是理解 作用机制。此外，许多膜蛋白需要构象。 灵活性才能发挥作用，这使得它必须获得动态 信息也是如此，以便充分了解功能。因此，一名少校 这一领域的问题是在获得结构上的固有困难 相关级别的决议信息。本次研讨会的目的是 将来自不同领域的广泛的关键调查人员聚集在一起 在分子水平上研究结构/功能关系的学科 参与多种功能的多孔膜蛋白从 尽可能地从不同的角度看待问题。没有其他这样的包罗万象的会议 专门针对这个问题的会议曾经举行过，预计到 将这些人聚集在一起，讨论将集中在 高分辨率结构-功能研究的重要性 这类重要的生物分子。因此，本次研讨会将涵盖 该地区在过去30年中发生的显著发展 几年，以及对未来的预兆。由于这一事实， 研讨会将是如此独特，对研究生的职业生涯至关重要 和博士后后续有兴趣进一步了解这些 继续深造。为此，我们鼓励各届会议主席邀请 尽可能年轻的调查人员。此外，还举办了一个关于“新兴市场”的研讨会 技术“和海报会议包括在节目中。我们还打算 积极鼓励研究生和博士后参加 会见并参加这些会议。