The function of hnrnp c in the telomerase holoenzyme

描述(由申请人提供) 天然人类端粒酶的大小可达3000Kd。这表明，许多人 这种核糖核蛋白的其他因素仍有待发现。这些 端粒酶相关因素可能影响细胞的组装、成熟、 端粒酶的功能和调节，从而影响其在 癌症和衰老。然而，人们对助词的了解相对较少 人类端粒酶的组成成分。我们已经确定了几种新的成分 端粒酶全酶。其中两个新的蛋白质包括hnRNP C1/C2， 已被牵连的hnRNP RNA结合蛋白家族成员 在过去的端粒生物学中发挥作用。我们建议确定 这些蛋白质在端粒酶和端粒生物学中发挥的作用 直接的方法。这里描述的研究将提供以下信息 可能允许在端粒酶中靶向这些新的因子 全酶和可能有一天导致癌症和衰老相关的治疗 精神错乱。

DESCRIPTION (provided by applicant) Native human telomerase can be as large as 3000Kd. This indicates that many additional factors of this ribonucleoprotein remain to be discovered. These telomerase-associated factors likely influence the assembly, maturation, function and regulation of telomerase and therefore, influence its role in cancer and aging. However, relatively little is known about the auxiliary components of human telomerase. We have identified several novel components of the telomerase holoenzyme. Two of the novel proteins include hnRNP C1/C2, members of the hnRNP family of RNA binding proteins that have been implicated to have roles in telomere biology in the past. We propose to determine the function these proteins play in telomerase and telomere biology using several direct approaches. The research described herein will provide information that could allow for the targeting of these novel factors in the telomerase holoenzyme and may one-day lead to the treatment of cancer and aging related disorders.