The function of hnrnp c in the telomerase holoenzyme

hnrnp c 在端粒酶全酶中的功能

• 批准号: 6503196
• 负责人: LANCE P FORD
• 金额: $ 3.27万
• 依托单位: AMBION, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6503196
• 关键词: RNA binding protein; aging; binding sites; cancer risk; cell component structure /function; cell line; confocal scanning microscopy; embryonic stem cell; enzyme activity; enzyme biosynthesis; gene expression; human tissue; immunocytochemistry; protein protein interaction; protein structure function; radionuclide double label; telomerase; telomere

DESCRIPTION (provided by applicant) Native human telomerase can be as large as 3000Kd. This indicates that many additional factors of this ribonucleoprotein remain to be discovered. These telomerase-associated factors likely influence the assembly, maturation, function and regulation of telomerase and therefore, influence its role in cancer and aging. However, relatively little is known about the auxiliary components of human telomerase. We have identified several novel components of the telomerase holoenzyme. Two of the novel proteins include hnRNP C1/C2, members of the hnRNP family of RNA binding proteins that have been implicated to have roles in telomere biology in the past. We propose to determine the function these proteins play in telomerase and telomere biology using several direct approaches. The research described herein will provide information that could allow for the targeting of these novel factors in the telomerase holoenzyme and may one-day lead to the treatment of cancer and aging related disorders.

描述（由申请人提供） 人类本地端粒酶可以高达3000kd。这表明许多 该核糖核蛋白的其他因素仍有待发现。这些 端粒酶相关因素可能影响组装，成熟， 端粒酶的功能和调节，因此影响其在 癌症和衰老。但是，关于辅助的知之甚少 人端粒酶的组成部分。我们已经确定了几个新颖的组成部分 端粒酶全酶。两种新型蛋白质包括HNRNP C1/C2， 与已与之相关的RNA结合蛋白的HNRNP家族的成员 过去曾在端粒生物学中发挥作用。我们建议确定 这些蛋白质在端粒酶和端粒生物学中发挥作用 直接方法。本文所述的研究将提供信息 可以允许在端粒酶中靶向这些新因素 Holoenzyme，可能一日导致癌症和衰老相关的治疗 疾病。