High throughput phenotyping: drug effects on homecage mo

描述（由申请人提供）：我们建议开发一种高通量的 快速自动表型筛选系统：药物对饲养笼的影响 在小鼠或大鼠中的行为。该项目的目的是确定是否 应用一种新的自动化程序对不同行为进行分类， 小鼠和大鼠能够可靠地预测药物诱导的变化， 行为提出的方法的主要优点是， 这项建议是，它将使调查人员能够执行非常复杂的家庭， 笼内行为分析，这在今天的技术下几乎是不可能的， 并进行大规模的筛选试验，以检查广泛的 在突变小鼠或大鼠中滥用各种不同的药物。这项技术 将提高观察老鼠行为的质量，减轻负担， 实现更客观、更持续的分析。我们的研究将实现 目标是开发和改进用于测量药物定向的自动化方法， 或相关行为，或用于测量对药物的行为反应， 滥用或潜在的治疗剂。这将包括两项研究 行为研究和计算机算法设计领域，以及 完整的系统集成。这项技术是基于我们的开发和 再利用数字视频分析和图像处理技术。 拟议商业应用：不可用

DESCRIPTION (provided by applicant): We proposed to develop a high-throughput system for rapid and automated phenotypic screen: drug effects on home-cage behavior in mice or rats. The purposes of the project are to determine whether the application of a new automated procedure to classify different behaviors in mice and rats is able to reliably predict drug-induced changes in home-cage behavior. The main advantage of the methods that are proposed to be used in this proposal is that it will enable investigators to perform very complex home cage behavior analysis that are almost impossible with today's technologies, and to conduct large scale screening tests to examine the effects of a wide variety of different drugs of abuse in mutant mice or rats. This technology will improve the quality, and alleviate the burden, of observing mouse behavior and achieve more objective and constant analysis. Our research will achieve the goal of developing and improving automated methods for measuring drug directed or related behaviors, or for measuring behavioral responsivity to drugs of abuse or potential therapeutic agents. This will include the studies in both areas of behavioral research and computer algorithm designs, as well as complete system integration. The technology is based on our developing and reusing digital video analysis and image processing technologies. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE