Digital Video Monitor and Analysis of Seizures with EEG

描述(由申请人提供)：啮齿类动物，主要是大鼠和小鼠的脑电发作的行为成分通常被用作癫痫发作存在的最基本的基础。许多研究拨款使用对动物癫痫发作的分析作为研究的基本组成部分，甚至是针对分子和细胞机制的研究。运动性癫痫发作期间的异常行为通常是独特的，但在不同的实验室之间存在一定程度的主观性。随着用于多次记录的复杂电极的开发和无线电遥测系统的可用，现在有可能将癫痫发作行为和脑电发作活动的自动化研究结合起来。我们建议开发和验证行为算法，以使用数字视频技术识别、分类和量化不同类型的小鼠和大鼠癫痫发作的运动成分。我们将定义不同类别癫痫发作的行为成分，并结合脑电记录中的脑电癫痫发作进行定义。这些行为将包括但不限于单侧和双侧前肢阵挛，以及采取具有特征的尾巴位置的前凸姿势。将全面开发一种允许脑电和行为联合分析的系统，以满足大学和制药公司研究实验室的需求。

DESCRIPTION (provided by applicant): The behavioral components of electrographic seizures in rodents, primarily rats and mice, are generally used as the most fundamental basis for the presence of epileptic seizures. Numerous research grants use analysis of animal seizures as a fundamental component of the research, even research aimed at molecular and cellular mechanisms. The abnormal behaviors during a motor seizure are generally distinctive, but a certain degree of subjectivity is present from one laboratory to another. With the development of sophisticated electrodes for multiple recordings and the availability of radiotelemetry systems, the potential to combine automated studies of seizure behavior and electrographic seizure activity is now possible. We propose to develop and validate behavioral algorithms for identifying, classifying and quantifying the motor components of different types of seizures in mice and rats using digital video technology. We will define the behavioral components of different classes of seizures, and to do this in conjunction with electrographic seizures from EEG recordings. These behaviors will include but not be limited to unilateral and bilateral forelimb clonus and the assumption of a lordotic posture, with a characteristic positioning of the tail. A system that allows combined analysis of EEG and behavior will be fully developed to meet the demand from research laboratories at universities and pharmaceutical companies.