Sleep Research with Digital Video Technologies

描述（由申请人提供）：小鼠为研究睡眠/觉醒调节（睡眠）提供了极好的遗传模型。睡眠和昼夜节律过程之间的相互作用。对小鼠睡眠状态的研究可能最终为人类睡眠控制提供见解。一个完整的表型描述的睡眠小鼠品系是必要的睡眠/觉醒控制的遗传分析。 睡眠研究一直受到技术限制的困扰，因为从EEG和EMG活动中识别睡眠一直是用于研究啮齿动物睡眠的主要技术。使用EEG和EMG进行睡眠分析的替代方案涉及使用关于啮齿动物的活动或行为的视觉观察数据。自动化这种视觉观察过程将是睡眠研究领域的一个重要里程碑。因此，我们建议开发方法和设计算法，以自动监测和分析啮齿动物的行为进行，期间和之后的睡眠，以促进睡眠研究。这项研究将涉及睡眠相关行为的确定，自动算法设计，以及包括视频，EEG和EMG在内的多模态信号的相关分析。 从商业角度来看，开发一个视频分析系统来对睡眠/清醒状态进行评分，将扩展Clever Sys Inc视频分析系统的功能。这种视频分析系统将有助于快速开发和分析睡眠障碍的新疗法，目前这是一个价值数千万美元的行业。

DESCRIPTION (provided by applicant): The Mouse provides an excellent genetic model for the study of sleep/wake regulation, sleep. Homeostasis and the interaction between sleep and circadian processes. Study of sleep states in mice may ultimately provide insight into the control of sleep in humans. A complete phenotypic description of sleep in mouse strains is necessary for the genetic analysis of sleep/wake control. Sleep research has been plagued with technological limitations because identifying sleep from EEG and EMG activity has been the primary technique used to study sleep in rodents. An alternative to using EEG and EMG for sleep analysis involves using visual observational data about the activities or behaviors of rodents. Automating such visual observation processes will be an important landmark in the field of sleep research. Therefore, we propose to develop methodologies and design algorithms to automate the monitoring and analysis of rodents' behaviors proceeding, during, and following sleep in order to facilitate sleep research. This proposed study would involve the determination of sleep-related behaviors, automated algorithm design, and the correlated analysis of multi-modal signals including video, EEG, and EMG. From a commercial perspective, the development of a video analysis system to score sleep/wake states will expand the capabilities of the Clever Sys Inc video analysis system. This video analysis system will assist the rapid development and analysis of novel treatments of sleep disorders, tens of millions dollar industry at present.