ULTRASONIC DETECTION OF MIDDLE EAR EFFUSION
中耳积液的超声检测
基本信息
- 批准号:6292930
- 负责人:
- 金额:$ 11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-15 至 2002-03-14
- 项目状态:已结题
- 来源:
- 关键词:auditory pathways bioengineering /biomedical engineering biomedical equipment development biosensor device biotechnology body fluid viscosity diagnosis design /evaluation diagnosis quality /standard ear disorder diagnosis eustachian tube exudate /transudate human subject middle ear noninvasive diagnosis otitis media patient oriented research physical model tympanoplasty ultrasonography
项目摘要
DESCRIPTION (Verbatim from the Abstract): Existing non-invasive diagnostic
methods for otitis media, such as tympanometry, have inadequate specificity and
sensitivity. Complications of undiagnosed OM can include hearing loss. In
combination, unsatisfactory diagnostic techniques and the gravity of the
complications and often lead to unnecessary over-medication of children. This
may in turn lead to the development of antibiotic resistance.
We will develop a non-invasive ultrasonic device that will detect the presence
of middle ear effusion with high accuracy, and it will distinguish the serous
or mucoid character of the fluid. The proposed detector will utilize novel
miniature broadband piezoelectric transducers developed at Case Western Reserve
University. The detection of effusion will be accomplished by analysis of the
echo reflected from the distal plane of the tvrnpanic membrane. The rheological
properties of the fluid will be determined by attenuation analysis of the echo
reflected from the wall of the inner ear. An in vitro study will be done on a
physical model of the human ear. After successful in vitro evaluation of the
detector, a limited clinical study will be conducted on patients scheduled for
tube placement. The performance of the detector will be compared to the results
obtained with myringotomy.
PROPOSED COMMERCIAL APPLICATION:
A new diagnostic device for otitis media will be developed. Otitis media prompts more than 24.5-30 million physician visits per year. The United States market size for treatment of otitis media is between $3-4 billion dollars annually.
描述(摘自摘要):现有的非侵入性诊断
用于中耳炎的方法如鼓室测压法的特异性不足,
灵敏度未确诊的OM的并发症可能包括听力损失。在
结合,不令人满意的诊断技术和严重的
并发症,往往导致儿童不必要的过度用药。这
可能反过来导致抗生素耐药性的发展。
我们将开发一种非侵入性的超声波设备,
中耳积液的准确性高,它将区分浆液性中耳积液,
或粘液性质的液体。所提出的探测器将利用新颖的
凯斯西储开发的微型宽带压电换能器
大学积液的检测将通过分析
从鼓膜远端平面反射的回声。流变
流体的性质将通过回波的衰减分析来确定
从内耳壁反射回来。体外研究将在
人耳的物理模型。在成功进行体外评价后,
检测器,将对计划接受
管放置。探测器的性能将与结果进行比较
鼓膜切开术获得的。
拟定商业应用:
将研制一种新的中耳炎诊断装置。中耳炎每年促使超过2450万至3000万的医生就诊。美国每年用于治疗中耳炎的市场规模在30 - 40亿美元之间。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(2)
Ultrasound characterization of middle ear effusion.
中耳积液的超声表征。
- DOI:10.1016/j.amjoto.2012.08.005
- 发表时间:2013
- 期刊:
- 影响因子:2.5
- 作者:Seth,Rahul;Discolo,ChristopherM;Palczewska,GrazynaM;Lewandowski,JanJ;Krakovitz,PaulR
- 通讯作者:Krakovitz,PaulR
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JAN JERZY LEWANDOWSKI其他文献
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- 批准号:
6692797 - 财政年份:2003
- 资助金额:
$ 11万 - 项目类别:
Low Cost, Accurate, Portable Blood Lead Analyzer
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- 批准号:
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- 资助金额:
$ 11万 - 项目类别:
Endothelial Adhesion Molecules and Leukocyte Egress
内皮粘附分子和白细胞排出
- 批准号:
7058852 - 财政年份:2001
- 资助金额:
$ 11万 - 项目类别: