Low Cost, Accurate, Portable Blood Lead Analyzer

低成本、准确的便携式血铅分析仪

• 批准号: 6484787
• 负责人: JAN JERZY LEWANDOWSKI
• 金额: $ 13万
• 依托单位: ELECTROSONICS MEDICAL INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484787
• 关键词: biomedical equipment development; diagnosis design /evaluation; electrical potential; electrochemistry; electrolytes; human tissue; lead poisoning; portable biomedical equipment; potentiometry; serology /serodiagnosis; toxicant screening

We will develop a low cost, accurate, portable blood lead analyzer. The device will utilize a unique miniature rotating microsample system, which can be incorporated into a fluidic chip. The electrochemistry of the system is equivalent to the performance of a typical rotating electrode but no moving mechanical parts are required. Anodic Stripping Voltammetry and Potential Stripping Analysis techniques will be evaluated. Based on preliminary data, it is expected that the device will be capable of providing blood lead determinations with the accuracy and sensitivity required by the CDC. Lead poisoning is the most common environmental health problem affecting children. The irreversible neurotoxic effects of childhood blood-lead at low concentrations, that do not cause immediate clinical symptoms, are now well documented. The present lack of inexpensive but accurate blood determination techniques prevents necessary widespread screening programs. Our device will be an order of magnitude cheaper than Atomic Absorption Spectroscopy systems and the blood lead analyses will be so inexpensive that widespread screening will be feasible. The proposed device can be easily adapted for determination of other toxic heavy metals such as mercury or cadmium. PROPOSED COMMERCIAL APPLICATIONS: The results of a cost-to-benefit analysis of blood level screening programs was presented in the CDC's report "Costs and benefits of Universal Screening Program for Elevated Lead Levels in 1 year old children". According to this document, the current average cost of blood lead screening is $60 per child. At this price the economic benefits of screening program exceed the costs of screening when the prevalence of the elevated blood level in the child population is 14% or greater. Our estimate is that the proposed device will reduce cost per assay to $10 or less. This will be accomplished by lowering of the direct cost of the assay and reducing the cost of sample withdrawal (finger piercing vs. venipuncture). Additionally the device will not require expensive, highly trained lab personnel to operate it.

我们将研制一种低成本、高精度、便携式的血铅分析仪。该设备将利用独特的微型旋转微量样品系统，该系统可以集成到流体芯片中。该系统的电化学性能相当于典型的旋转电极，但不需要移动机械部件。 将评价阳极溶出伏安法和电位溶出分析技术。根据初步数据，预计该设备将能够提供CDC要求的准确度和灵敏度的血铅测定。铅中毒是影响儿童的最常见的环境健康问题。儿童血铅在低浓度下不可逆转的神经毒性作用，不会引起立即的临床症状，现在已经有充分的记录。目前缺乏廉价但准确的血液测定技术，阻碍了必要的广泛筛查计划。我们的设备将比原子吸收光谱系统便宜一个数量级，血铅分析将如此便宜，以至于广泛的筛查将是可行的。所提出的装置可以很容易地适用于其他有毒重金属，如汞或镉的测定。拟议的商业应用：血液水平筛查计划的成本效益分析结果在CDC的报告“1岁儿童铅水平升高的普遍筛查计划的成本和效益”中提出。根据这份文件，目前血铅筛查的平均费用为每个儿童60美元。在这个价位上，当儿童人群中血液水平升高的患病率为14%或更高时，筛查计划的经济效益超过了筛查的成本。我们的估计是，拟议的设备将降低每次检测的成本至10美元或更低。这将通过降低检测的直接成本和降低样本提取的成本（手指穿刺与静脉穿刺）来实现。此外，该设备将不需要昂贵的，训练有素的实验室人员来操作它。