BIOMIMETIC COATING FOR CENTRAL VENOUS CATHETERS

中心静脉导管仿生涂层

• 批准号: 6337718
• 负责人: JAN JERZY LEWANDOWSKI
• 金额: $ 13.45万
• 依托单位: ELECTROSONICS MEDICAL INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337718
• 关键词: adhesions; adsorption; biomaterial development /preparation; biomimetics; catheterization; dogs; fibrinogen; platelets; polymers; surface coating; surfactant; thrombosis

Approximately 80% of patients require an intravenous catheter upon hospitalization, and thrombosis (fibrin sheath formation and mural thrombosis) results in a 25 % failure rate. Blood compatible coatings have been investigated in recent years in order to improve material biocompatibility by reducing thrombogenicity through diminished protein adhesion. One of the more promising types of surface biolization technologies is a surfactant polymer coating that attempts to mimic nature, in particular the properties of endothelium. Hydrophobic groups provide surfactant polymer adhesion to the foreign surface and hydrophilic blood-compatible outer groups form an interface with blood flow reducing fibrinogen and platelet adhesion, and thus consequently, thrombus formation. In Phase I of the project, we will determine stability of the surfactant coating on polyurethane through in vitro shear studies corresponding to shear rates experienced by a catheter. Further, a series of ex vivo experiments will be conducted to determine fibrinogen and platelet adsorption to surfactant coated polyurethane surfaces. It is expected that fibrinogen and platelet adhesion will be reduced by at least 80% compared to control materials. If successful, this will demonstrate the feasibility of surfactant coating for venous catheters. PROPOSED COMMERCIAL APPLICATIONS: Catheter improvements have shown cost savings, with a simple improvement in catheter securement resulting in a 76% reduction in unscheduled nurse visits and a 68% decrease in unscheduled catheter restarts. Such improvement could cut costs by more than $58 per patient per month. In 1998, the worldwide catheter market was $4.41 billion and it is expected to grow to $5.78 billion by the year 2002. In the US the market is expected to grow over $2 billion by 2002. Beyond the immediate application, the surfactant polymer biomimetic coating is designed to be easy to apply (dip coating) and can be tailored to any surface. Even sharing a small percentage of this market through coating services or licensing technology would represent significant income.

大约80%的患者在住院时需要静脉内导管，血栓形成（纤维蛋白鞘形成和附壁血栓形成）导致25%的失败率。近年来研究了血液相容性涂层，以通过减少蛋白质粘附来减少血栓形成，从而改善材料的生物相容性。表面生物化技术的更有前途的类型之一是表面活性剂聚合物涂层，其试图模拟自然，特别是内皮的性质。疏水性基团提供表面活性剂聚合物粘附到外来表面，并且亲水性血液相容性外部基团形成与血流的界面，从而减少纤维蛋白原和血小板粘附，并因此减少血栓形成。在项目的第I阶段，我们将通过与导管经历的剪切速率相对应的体外剪切研究来确定聚氨酯上表面活性剂涂层的稳定性。此外，将进行一系列离体实验以确定纤维蛋白原和血小板对表面活性剂涂覆的聚氨酯表面的吸附。与对照材料相比，预计纤维蛋白原和血小板粘附将减少至少80%。如果成功，这将证明静脉导管表面活性剂涂层的可行性。拟议的商业应用：导管改进已显示出成本节约，导管固定的简单改进导致计划外护士访视减少76%，计划外导管重新启动减少68%。这样的改善可以减少每个病人每月58美元以上的费用。1998年，全球导管市场为44.1亿美元，预计到2002年将增长到57.8亿美元。在美国，预计到2002年市场将增长超过20亿美元。除了直接应用外，表面活性剂聚合物仿生涂层设计易于应用（浸涂），并可针对任何表面进行定制。即使通过涂层服务或许可技术分享这一市场的一小部分，也将带来可观的收入。