BIOMIMETIC COATING FOR CENTRAL VENOUS CATHETERS

大约80%的患者在住院时需要静脉导管，而血栓形成（纤维蛋白鞘形成和壁血栓形成）导致25%的失败率。近年来研究了血液相容性涂层，通过减少蛋白质粘附来降低血栓形成性，从而改善材料的生物相容性。一种更有前途的表面生物化技术是表面活性剂聚合物涂层，它试图模仿自然，特别是内皮细胞的特性。疏水基团提供表面活性剂聚合物粘附到异物表面，亲水的血液相容的外基团与血流形成界面，减少纤维蛋白原和血小板粘附，从而形成血栓。在项目的第一阶段，我们将通过导管所经历的剪切速率的体外剪切研究来确定表面活性剂涂层在聚氨酯上的稳定性。此外，将进行一系列离体实验，以确定纤维蛋白原和血小板在表面活性剂涂层聚氨酯表面的吸附。预计与对照材料相比，纤维蛋白原和血小板粘附将至少降低80%。如果成功，这将证明表面活性剂涂层用于静脉导管的可行性。建议的商业应用：导管改进已显示出成本节约，导管安全的简单改进可使计划外护士就诊减少76%，计划外导管重新启动减少68%。这种改善可以为每位患者每月节省58美元以上的费用。1998年，全球导管市场为44.1亿美元，预计到2002年将增长到57.8亿美元。在美国，预计到2002年该市场将增长到20亿美元以上。除了即时应用之外，表面活性剂聚合物仿生涂层的设计易于应用（浸涂），并且可以定制任何表面。即使通过涂层服务或许可技术分享这个市场的一小部分，也会带来可观的收入。

Approximately 80% of patients require an intravenous catheter upon hospitalization, and thrombosis (fibrin sheath formation and mural thrombosis) results in a 25 % failure rate. Blood compatible coatings have been investigated in recent years in order to improve material biocompatibility by reducing thrombogenicity through diminished protein adhesion. One of the more promising types of surface biolization technologies is a surfactant polymer coating that attempts to mimic nature, in particular the properties of endothelium. Hydrophobic groups provide surfactant polymer adhesion to the foreign surface and hydrophilic blood-compatible outer groups form an interface with blood flow reducing fibrinogen and platelet adhesion, and thus consequently, thrombus formation. In Phase I of the project, we will determine stability of the surfactant coating on polyurethane through in vitro shear studies corresponding to shear rates experienced by a catheter. Further, a series of ex vivo experiments will be conducted to determine fibrinogen and platelet adsorption to surfactant coated polyurethane surfaces. It is expected that fibrinogen and platelet adhesion will be reduced by at least 80% compared to control materials. If successful, this will demonstrate the feasibility of surfactant coating for venous catheters. PROPOSED COMMERCIAL APPLICATIONS: Catheter improvements have shown cost savings, with a simple improvement in catheter securement resulting in a 76% reduction in unscheduled nurse visits and a 68% decrease in unscheduled catheter restarts. Such improvement could cut costs by more than $58 per patient per month. In 1998, the worldwide catheter market was $4.41 billion and it is expected to grow to $5.78 billion by the year 2002. In the US the market is expected to grow over $2 billion by 2002. Beyond the immediate application, the surfactant polymer biomimetic coating is designed to be easy to apply (dip coating) and can be tailored to any surface. Even sharing a small percentage of this market through coating services or licensing technology would represent significant income.