Iridium-Oxide Based Sensor for Blood pH/pCO2 Monitoring

用于血液 pH/pCO2 监测的氧化铱传感器

• 批准号: 6692797
• 负责人: JAN JERZY LEWANDOWSKI
• 金额: $ 16.39万
• 依托单位: ELECTROSONICS MEDICAL INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2004-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6692797
• 关键词: acid base balance; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; carbon dioxide; iridium; metal oxide; microelectrodes; miniature biomedical equipment; monitoring device; oximetry; respiratory gas analyzer

DESCRIPTION (provided by applicant): Measurement of arterial blood gases is one of the most frequently performed tests on critically ill patients. Determination of blood gas concentrations (such as pCO2) is conducted by intermittent sampling and analysis using a bench-top analyzer. However, results are not ready until several minutes after the blood samples are taken, and these delayed data may not reflect actual patient status. Continuous blood gas determination would allow for immediate detection of changes in the status of ICU patients, of patients with acute respiratory disorders, and of patients undergoing major surgery (such as bypass surgery). To date, the lack of reliable and inexpensive miniature sensors has been a critical factor preventing wide use of continuous in-vivo gasometry. We have devised a novel approach, using the enabling technology of pH sensors based on the novel molted carbonate iridium oxide (IrOx) deposition process. This technique will allow for commercial products of miniature sensors for continuous monitoring of blood pH and pCO2 levels. In Phase I, our goal is to develop such prototype sensors and to demonstrate their feasibility. Our reserch will be focused on development of solid electrolyte membranes for blood pH and blood pCO2 sensors. Further we will investigate fesibility of silicone carbide micrifabrication technology for mass _roduction of the sensors. In Phase II, we will refine the design, optimize microfabrication process and !perform the necessary development steps towards human testing. Our ultimate aim is to develop commercial devices that will utilize this sensor, such as cannulae for open-heart surgery.

描述（由申请人提供）： 动脉血气的测量是危重患者最常进行的检查之一。 血气浓度（如pCO 2）的测定通过间歇采样和使用台式分析仪进行分析。然而，结果要在血液样本采集后几分钟才能准备好，这些延迟的数据可能无法反映患者的实际状态。连续血气测定将允许立即检测ICU患者、患有急性呼吸系统疾病的患者和经历大手术（例如旁路手术）的患者的状态变化。迄今为止，缺乏可靠且廉价的微型传感器一直是阻碍连续体内气体测定法广泛使用的关键因素。我们已经设计了一种新的方法，使用基于新的熔融碳酸盐氧化铱（IrOx）沉积过程的pH传感器的使能技术。该技术将允许微型传感器的商业产品用于连续监测血液pH值和pCO 2水平。在第一阶段，我们的目标是开发这样的原型传感器，并证明其可行性。本课题的研究重点是开发用于血液pH和血液pCO 2传感器的固体电解质膜。进一步探讨了碳化硅微细加工技术用于传感器大规模生产的可行性。在第二阶段，我们将完善设计，优化微加工工艺和！进行必要的开发步骤，以进行人体试验。我们的最终目标是开发将利用这种传感器的商业设备，例如用于心脏直视手术的插管。