课题基金 / 基金详情

APOPTOSIS-INDUCING ANTIMITOTIC AGENTS FOR CANCER THERAPY

APOPTOSIS-INDUCING ANTIMITOTIC AGENTS FOR CANCER THERAPY
用于癌症治疗的细胞凋亡诱导抗有丝分裂剂
批准号:
6298857
负责人:
SUI X CAI
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-01 至 2002-02-28

项目摘要

项目成果

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相关文献

中文摘要
翻译
描述:Cytovia发现了一类新的抗有丝分裂药物
英文摘要
DESCRIPTION: Cytovia has discovered a new class of antimitotic agents which are potent inducers of apoptosis and strong inhibitors of tumor cell growth. Preliminary experiments indicate that these compounds block mitosis by inhibiting the polymerization of tubulin, disrupting microtubule function, and triggering G2/M arrest. They can also inhibit the in vitro growth of multidrug resistant cell lines, which suggests that they may prove useful in the treatment of drug-resistant cancers. Because these compounds are small synthetic organic molecules, rather than natural products like the conventional antimitotic agents, they can be synthesized and modified readily to produce a wide variety of analogs. The current grant application proposes to characterize the in vivo properties of these novel agents using the athymic nude mouse cancer model. The application also proposes to design and synthesize analogs of these compounds, in a search for next-generation antimitotic agents with optimized chemical and biological properties. The results of the proposed experiments will provide critical information about the chemistry and pharmacology of these antimitotic agents and will help identify candidates for detailed pre-clinical testing and clinical trials. PROPOSED COMMERCIAL APPLICATION: The antimitotic agents that we propose to study in this application appear to have properties that are superior to other anticancer drugs, including other antimitotic agents. If successfully developed, these novel agents may capture a substantial portion of the market for antimitotics cancer drugs, which for the taxanes alone may exceed $2 billion in the year 2000.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1158/1535-7163.1365.3.11
发表时间: 2004-11
期刊: Molecular cancer therapeutics
影响因子: 5.7
作者: [S. Kasibhatla;H. Gourdeau;K. Meerovitch;J. Drewe;Sanjeeva P. Reddy;L. Qiu;Hong Zhang;F. Bergeron]
通讯作者: S. Kasibhatla;H. Gourdeau;K. Meerovitch;J. Drewe;Sanjeeva P. Reddy;L. Qiu;Hong Zhang;F. Bergeron
海外基金