DISPOSITION OF CODEINE IN HAIR & SALIVA: EFFECT OF GENDER & HAIR COLOR

头发中可待因的处置

• 批准号: 6304886
• 负责人: DOUGLAS E ROLLINS
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304886
• 关键词: clinical research; codeine; drug detection; gender difference; hair; human subject; pharmacokinetics; pigmentation; saliva

Hair and saliva are being proposed as alternatives to testing urine and blood for the detection of drug use. Analysis of a hair specimen is less invasive, more reliable and more sensitive than urine as an indicator of drug use, yet urine is utilized in most drug detection programs. The caveat about the use of hair analysis to detect drugs of abuse is that factors known and unknown affect the concentraton of drugs in hair. For example, Dr. Rollins and his colleagues have demonstrated that the concentration of opiates in the hair of women is substantially greater than in males. Similarly, drug concentration is greater in pigmented hair than in non-pigmented hair. Although saliva is being used increasingly for the detection of drugs of abuse, gender and race-related factors affecting drug concentration in this easily accessed body fluid have not been extensively studied. This study is designed to determine the effects of gender, hair color and ethnicity on the concentration of drugs of abuse in hair and saliva. Oflaxicin, a quinotone antibiotic, will be used as a surrogate marker for opiates.

有人提议用毛发和唾液来代替尿液和血液来检测药物使用情况。与尿液相比，毛发样本的分析侵入性更小，更可靠，更敏感，作为药物使用的指标，然而尿液被用于大多数药物检测项目。关于使用头发分析来检测药物滥用的警告是，已知和未知的因素会影响头发中的药物浓度。例如，罗林斯博士和他的同事们已经证明，女性头发中的阿片类药物浓度远远高于男性。同样，药物浓度在有色素的头发中比在没有色素的头发中更高。虽然越来越多地使用唾液来检测滥用药物，但影响这种容易获得的体液中药物浓度的与性别和种族有关的因素尚未得到广泛研究。本研究旨在确定性别、发色和种族对头发和唾液中滥用药物浓度的影响。Oflaxicin，一种喹诺酮类抗生素，将被用作阿片类药物的替代标记物。