DISPOSITION OF CODEINE IN HAIR & SALIVA: EFFECT OF GENDER & HAIR COLOR

头发中可待因的处置

• 批准号: 6425937
• 负责人: DOUGLAS E ROLLINS
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6425937
• 关键词: clinical research; codeine; drug detection; gender difference; hair; human subject; pharmacokinetics; pigmentation; saliva

Hair and saliva are being proposed as alternatives to testing urine and blood for detecting drug use. The objectives of this project are to determine the effect of hair color and gender on the incorporation of codeine and ofloxacin into human hair, and to determine the saliva concentration of codeine. Thirty-seven subjects have been entered into the study. The analysis of ofloxacin in hair has been completed in thirty-five subjects. Subjects with black hair had the highest concentration of drug in the hair sampled, and patients with red hair had the lowest. Patients with blond or brown hair had intermediate values. These preliminary data suggest that there is an effect of hair color on the distribution of ofloxacin into hair. Additional volunteers with dark-colored hair are now being recruited, and ofloxacin concentration will be measured in plasma and hair of these subjects. Measures of codeine concentration in plasma, urine, hair, and saliva of all subjects enrolled is under way.

头发和唾液被提议作为检测毒品使用的尿液和血液的替代品。 该项目的目标是确定头发颜色和性别对可待因和氧氟沙星掺入人体头发的影响，并确定可待因的唾液浓度。 37例受试者已入组研究。 对35名受试者进行了头发中氧氟沙星的分析。 黑发受试者的头发样本中药物浓度最高，红发患者最低。 金发或棕色头发的患者具有中间值。 这些初步数据表明，头发颜色对氧氟沙星在头发中的分布有影响。 目前正在招募更多深色头发的志愿者，并将测量这些受试者血浆和头发中的氧氟沙星浓度。 正在对所有受试者的血浆、尿液、毛发和唾液中的可待因浓度进行测量。