DISPOSITION OF CODEINE IN HAIR & SALIVA: EFFECT OF GENDER & HAIR COLOR

有人提议用毛发和唾液来代替尿液和血液来检测药物使用情况。该项目的目的是确定头发颜色和性别对可待因和氧氟沙星入人头发的影响，并确定唾液中可待因的浓度。共有37名受试者参加了这项研究。完成了35例头发中氧氟沙星的分析。黑头发受试者的头发样本中药物浓度最高，红头发受试者的浓度最低。金发或棕色头发的患者则处于中间值。这些初步数据表明，头发颜色对氧氟沙星在头发中的分布有影响。目前正在招募更多深色头发的志愿者，并将测量这些受试者血浆和头发中的氧氟沙星浓度。正在测量所有受试者血浆、尿液、毛发和唾液中的可待因浓度。

Hair and saliva are being proposed as alternatives to testing urine and blood for detecting drug use. The objectives of this project are to determine the effect of hair color and gender on the incorporation of codeine and ofloxacin into human hair, and to determine the saliva concentration of codeine. Thirty-seven subjects have been entered into the study. The analysis of ofloxacin in hair has been completed in thirty-five subjects. Subjects with black hair had the highest concentration of drug in the hair sampled, and patients with red hair had the lowest. Patients with blond or brown hair had intermediate values. These preliminary data suggest that there is an effect of hair color on the distribution of ofloxacin into hair. Additional volunteers with dark-colored hair are now being recruited, and ofloxacin concentration will be measured in plasma and hair of these subjects. Measures of codeine concentration in plasma, urine, hair, and saliva of all subjects enrolled is under way.