COMPARISON OF PLASMA, WHOLE BLOOD, URINE AND HAIR CONCENTRATION OF ALPRAZOLAM

阿普唑仑血浆、全血、尿液和头发浓度的比较

• 批准号: 6245947
• 负责人: DOUGLAS E ROLLINS
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245947
• 关键词: alprazolam; blood chemistry; clinical research; drug detection; drug metabolism; gas chromatography; gender difference; hair; human subject; mass spectrometry; plasma; urinalysis

The goal of this study is to test the hypothesis that alprazolam is detectable in hair samples and is correlated with plasma and whole blood concentrations. Unconjugated alprazolam and a-hydroxyalprazolam in plasma, whole blood, urine and hair will be analyzed by gas chromatography and mass spectrometry. These data will be used to determine the length of time required for the drug to appear in hair, concentration, dose-response relationship, gender differences in hair concentrations, and the effects of hair washing on drug concentration.

本研究的目的是检验阿普唑仑是 在头发样本中可检测到，并与血浆和全血相关 浓度的 非结合阿普唑仑和α-羟基阿普唑仑 血浆、全血、尿液和毛发将通过气体分析 色谱法和质谱法。 这些数据将用于 确定药物出现在毛发中所需的时间长度， 浓度，剂量反应关系，毛发性别差异 浓度，以及洗发对药物浓度的影响。