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COMPARISON OF PLASMA, WHOLE BLOOD, URINE AND HAIR CONCENTRATION OF ALPRAZOLAM

COMPARISON OF PLASMA, WHOLE BLOOD, URINE AND HAIR CONCENTRATION OF ALPRAZOLAM
阿普唑仑血浆、全血、尿液和头发浓度的比较
批准号:
6245947
负责人:
DOUGLAS E ROLLINS
金额:
$2.15万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-03-06 至 1997-11-30

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中文摘要
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英文摘要
The goal of this study is to test the hypothesis that alprazolam is detectable in hair samples and is correlated with plasma and whole blood concentrations. Unconjugated alprazolam and a-hydroxyalprazolam in plasma, whole blood, urine and hair will be analyzed by gas chromatography and mass spectrometry. These data will be used to determine the length of time required for the drug to appear in hair, concentration, dose-response relationship, gender differences in hair concentrations, and the effects of hair washing on drug concentration.
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海外基金