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Using biological metaldehyde degradation for bioremediation and diagnostics

利用生物甲醛降解进行生物修复和诊断

基本信息

批准号：
1792587
负责人：
金额：
--
依托单位：
University of York
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1792587
关键词：
Using biological metaldehyde degradation bioremediation

项目摘要

Metaldehyde is a molluscicide used to kill slugs, thus protecting economically important crops, particularly potatoes, wheat and oil-seed rape. Following its use, metaldehyde runs off agricultural land and can accumulate in river and reservoir water, ultimately contaminating drinking water where it is recalcitrant to degradation. An EU defined maximum concentration in drinking water for this compound of 0.1 g/L has to be achieved, yet as currently operated metaldehyde passes through most water treatment works relatively untouched. Control of metaldehyde contamination is a priority issue for Water Companies in the UK (metaldehyde was responsible for 232/253 failures in water quality tests in England in 2012). There is currently no cost effective and reliable process for metaldehyde degradation. The difficult situation is exacerbated by a reliance on laborious laboratory-based chromatographic procedures required for metaldehyde measurement.This NERC-funded CASE studentship aims to rectify this problem by developing the application of naturally occurring microbiological degradation as a new solution for metaldehyde contamination. In a second strand of the project, we will exploit biological metaldehyde degradation mechanisms to design metaldehyde biosensors, thus leading to the creation of a new approach for field-testing of metaldehyde. A student with a background in microbiology, biotechnology and/or biochemistry who is prepared to work in an interdisciplinary way will be well equipped to take on this project, which will build upon earlier findings at York with respect to biological degradation of metaldehyde. Major objectives of the project are to: (i) improve existing bacterial isolates that can degrade metaldehyde to improve their properties for drinking water treatment, (ii) characterise the enzyme system for metaldehyde degradation to inform strain improvement and develop of sensor technology, (iii) develop electronic and optical methods for metaldehyde detection using biological components as biosensors.This project is a collaboration between the University of York (led by Dr. James Moir in the Department of Biology, with Dr. Steven Johnson, Department of Electronics as a co-supervisor) and Thames Water and the Food and Environment Research Agency (FERA Science Limited). The project will involve work at the University of York, at FERA (situated just outside York) and a significant industrial placement with Thames Water (using their water treatment research facilities in London).

三聚乙醛是一种杀软体动物剂，用于杀死蛞蝓，从而保护重要的经济作物，特别是马铃薯、小麦和油菜。使用后，四聚乙醛会从农田中流失，并会在河流和水库中积累，最终污染饮用水，使其难以降解。必须达到欧盟规定的饮用水中该化合物的最大浓度0.1 g/L，但由于目前运行的四聚乙醛通过大多数水处理工程相对未受影响。控制四聚乙醛污染是英国水务公司的首要问题（2012年，英格兰253次水质测试中有232次未通过四聚乙醛）。目前没有成本有效且可靠的四聚乙醛降解方法。由于四聚乙醛测量需要费力的基于实验室的色谱程序，这种困难的情况更加严重。这个由NERC资助的CASE学生项目旨在通过开发自然发生的微生物降解作为四聚乙醛污染的新解决方案来纠正这个问题。在该项目的第二部分，我们将利用生物四聚乙醛降解机制来设计四聚乙醛生物传感器，从而创建一种新的现场测试四聚乙醛的方法。具有微生物学，生物技术和/或生物化学背景的学生，准备以跨学科的方式工作，将有能力承担这个项目，该项目将建立在约克关于四聚乙醛生物降解的早期发现基础上。该项目的主要目标是：（i）改进现有的可以降解四聚乙醛的细菌分离物以改善它们用于饮用水处理的性质，（ii）改进用于四聚乙醛降解的酶系统以告知菌株改进和传感器技术的开发，（三）利用生物元件作为生物传感器，开发电子和光学方法检测四聚乙醛。该项目是与美国大学合作，约克（由生物系的詹姆斯·莫尔博士领导，电子系的史蒂文·约翰逊博士担任共同主管）和泰晤士水和食品与环境研究机构（FERA科学有限公司）。该项目将涉及在约克大学FERA（位于约克外）的工作，以及与泰晤士水务公司的重要工业布局（使用他们在伦敦的水处理研究设施）。