课题基金 / 基金详情

PROSPECTIVE STUDY TO DETERMINE THE EFFICACY AND SAFETY OF AZATHIOPRINE

PROSPECTIVE STUDY TO DETERMINE THE EFFICACY AND SAFETY OF AZATHIOPRINE
确定硫唑嘌呤功效和安全性的前瞻性研究
批准号：
6304925
负责人：
Robert E Shaddy
金额：
$0.16万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6304925
关键词：
azathioprine child (0-11) clinical research clinical trial phase I drug adverse effect drug screening /evaluation heart surgery homologous transplantation human subject human therapy evaluation immunotherapy pediatric pharmacology

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中文摘要
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英文摘要
In this study, the effect of a drug that suppresses the immune system was studied on children who received a human autopsy valve at the time of surgery for repair of a congenital heart defect. To do this, one-half of the children received this medication and the other one-half did not. Blood samples were drawn on all children 1 week, 1 month, and 3 months after surgery and the immune response of the children to the human autopsy valve was measured. Heart ultrasound tests were obtained to see whether there was any difference between the 2 groups with regard to valve function. No difference was found between groups with regard to the immune response or valve function.
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