CARDIOPULMONARY BYPASS OR PIECES OF HUMAN NON VALVED ALLOGRAFTS

体外循环或人体无瓣膜同种异体移植物

• 批准号: 6304885
• 负责人: Robert E Shaddy
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304885
• 关键词: child (0-11); clinical research; congenital heart disorder; cryopreservation; heart surgery; histocompatibility antigens; homologous transplantation; human subject; human therapy evaluation; transplantation immunology

Human non-valved allografts in pediatric congenital heart disease surgery: Is an antibody response elicited in the recipient?The hypothesis being tested in this study is that implantation of a human allograft during pediatric cardiac surgery causes an antibody response in the recipient, which accelerates allograft calcification and dysfunction. The specific aim of this protocol is to determine if allograft implantation induces an antibody response in the recipient manifested as an elevated panel-reactive antibody (PRA) in the recipient.

儿童先天性心脏病手术中的人类非瓣膜同种异体移植物：是否在受体中引起抗体反应？本研究中检验的假设是，在小儿心脏手术期间植入人类同种异体移植物会导致受体产生抗体反应，从而加速同种异体移植物钙化和功能障碍。 该方案的具体目的是确定同种异体移植是否诱导受体中的抗体应答，表现为受体中的群体反应性抗体（PRA）升高。