GENETIC POLYMORPHISMS IN CHILDREN WITH CONGENITAL HEART DISEASE

先天性心脏病儿童的基因多态性

• 批准号: 7718531
• 负责人: Robert E Shaddy
• 金额: $ 0.06万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718531
• 关键词: Biopsy; Blood; Child; Computer Retrieval of Information on Scientific Projects Database; DNA; Frequencies; Funding; GTP-Binding Proteins; Genes; Genetic Polymorphism; Grant; HRAS gene; Hypoplastic Left Heart Syndrome; Infant; Institution; Measures; Patients; Postoperative Period; Purpose; Receptors, Adrenergic, alpha-2; Research; Research Personnel; Resources; Sampling; Single Nucleotide Polymorphism; Skin; Source; Transposition of Great Vessels; United States National Institutes of Health; Ventricular Function; beta-adrenergic receptor; congenital heart disorder; mortality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the frequency of specific beta-adrenergic receptor, G-protein, Alpha 2-adrenergic receptor, Erk2 and H-Ras single nucleotide polymorphisms (SNP's) in a sample of children with congenital heart disease, specifically hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (dTGA). Specific SNP's will be correlated with post-operative inotropic requirements, measures of ventricular function, and mortality. Blood will be drawn or skin biopsies will be obtained (infants) from study patients for the purpose of DNA isolation and determination of SNP's of the above-stated genes.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在检测先天性心脏病，特别是左心发育不良综合征(HLHS)和大动脉转位(DTGA)患儿的β-肾上腺素能受体、G蛋白、α2-肾上腺素能受体、ERK2和H-RAS单核苷酸多态(SNP‘s)的频率。特定的SNP将与术后肌力需求、心功能测量和死亡率相关。将从研究患者身上抽取血液或进行皮肤活检(婴儿)，以进行DNA分离和上述基因的SNP测定。