GENETIC POLYMORPHISMS IN CHILDREN WITH CONGENITAL HEART DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是检查特定β-肾上腺素能受体，G-蛋白，α 2-肾上腺素能受体，Erk 2和H-Ras单核苷酸多态性（SNP）的先天性心脏病，特别是发育不良性左心综合征（HLHS）和d-大动脉转位（dTGA）的儿童样本的频率。 特定SNP将与术后正性肌力需求、心室功能测量和死亡率相关。将从研究患者（婴儿）抽取血液或获得皮肤活检，用于DNA分离和测定上述基因的SNP。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the frequency of specific beta-adrenergic receptor, G-protein, Alpha 2-adrenergic receptor, Erk2 and H-Ras single nucleotide polymorphisms (SNP's) in a sample of children with congenital heart disease, specifically hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (dTGA). Specific SNP's will be correlated with post-operative inotropic requirements, measures of ventricular function, and mortality. Blood will be drawn or skin biopsies will be obtained (infants) from study patients for the purpose of DNA isolation and determination of SNP's of the above-stated genes.