Quantification of Drusen in Macular Degeneration

黄斑变性中玻璃膜疣的量化

• 批准号: 6420119
• 负责人: THOMAS R FRIBERG
• 金额: $ 14.97万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420119
• 关键词: angiogenesis; biomarker; cataract; clinical research; computer program /software; digital imaging; disease /disorder proneness /risk; eye disorder diagnosis; eye fundus photography; eye laser surgery; human data; longitudinal human study; macular degeneration; macular drusen; nutrition; pathologic process; photocoagulation therapy; vitamins

DESCRIPTION: (Applicant's Abstract) Age-related macular degeneration (AMD) is the most common cause of blindness in the United Sates in Americans over the age of 50. Drusen are by-products of rod and cone metabolism and their presence in the ocular fundus is a clinical sign of AMD. It is known that patients whose eyes harbor drusen are at special risk of visual loss from AMD. In a prospective, multi-centered trial, the Age-Related Eye Disease Study (AREDS), some 5000 patients have been enrolled and followed at six-month intervals to determine risk factors for AMD as well as to measure the influence of certain multivitamins and micronutrients on the progression of macular degeneration and cataract. In another prospective, randomized, controlled trial, the Prophylactic Treatment of AMD Trial (PTAMD), patients with multiple large drusen have been enrolled to determine whether a minimal laser treatment applied one time provides any benefit with respect to lowering rates of visual loss and rates of development of choroidal neovascularization (CNVM). During the PTAMD and AREDS trials, photographs of the fundi of each participant have been taken at least annually in the form of Ektachrome color slides. These slides are evaluated by human readers in a Reading Center and the extent of the drusen is categorized accordingly. The applicant proposes to perform a quantitative analysis on the color slides of the macula of all patients who have been enrolled into the PTAMD and AREDS trials at the Pittsburgh site, as well as other patients who have AMD and have been followed similarly for a minimum of three years. The original slides will be digitized onto CD disks for permanent archiving, and will be analyzed using a specially-written computer algorithm which semi-automatically detects drusen in digital images. Once detected, quantitative measurements of the area of drusen extent and size of each drusen are generated for each image. This method is more precise than characterizing drusen using traditional long and more subjective protocols, and may be valuable in determining the risks of a given patient developing choroidal neovascularization and visual loss before such events occur. That is, such continuous quantitative data may, when analyzed, provide a more accurate and sensitive assessment of risk compared to conventional measurement techniques.

描述：（申请人的摘要）视网膜相关性黄斑变性（AMD）是 美国最常见的致盲原因是 50岁玻璃疣是视杆细胞和视锥细胞代谢的副产物， 是AMD的临床体征。据了解， 患有玻璃疣的眼睛有因AMD而导致视力丧失的特殊风险。中 前瞻性、多中心试验，眼动相关眼病研究（AREDS）， 大约5000名患者被招募，并每隔6个月进行一次随访， 确定AMD的风险因素，以及测量某些因素的影响， 多种维生素和微量营养素对黄斑变性进展的影响， 白内障在另一项前瞻性随机对照试验中， 预防性治疗AMD试验（PTAMD），多个大的 玻璃疣已经登记，以确定是否有最小的激光治疗， 施用一次提供了关于降低视觉损害率的任何益处。 脉络膜新生血管（CNVM）的损失和发展速率。期间 在PTAMD和AREDS试验中，每个参与者的眼底照片 至少每年以Ektachrome彩色幻灯片的形式拍摄。这些 幻灯片由人类读者在阅读中心评估， 玻璃疣被相应地分类。 申请人建议对彩色载玻片进行定量分析 所有入组PTAMD和AREDS的患者的黄斑 在匹兹堡的试验，以及其他患有AMD的患者， 至少三年的类似跟踪。原始幻灯片将 数字化到CD盘上永久存档，并将使用 一种专门编写的计算机算法， 在数字图像中。一旦被检测到， 为每个图像生成每个玻璃疣的玻璃疣程度和大小。该方法 比使用传统的长时间和更长的时间来表征玻璃疣更精确， 主观协议，并可能是有价值的，在确定风险的给定 患者在此之前发生脉络膜新生血管和视力丧失 事件发生。也就是说，当分析时， 提供更准确和敏感的风险评估， 传统测量技术。