Core--MR Methods for Functional and Physiologic Imaging

我们建议保持和改进磁共振(MR)方法，用于脑功能成像(FMRI)、解剖成像、扩散张量成像(DT-MRI，包括各向同性扩散成像和扩散各向异性成像)，以及基于DT-MRI的神经元纤维路径跟踪。该核心将为研究正常和缺血人脑的脑功能和结构，以及确定缺血性脑损伤的特征，在整个计划、项目授权期内提供一套一致和可靠的工具。这些工具将有助于在实验内和实验之间以及三个项目之间比较磁共振数据。在授予期间，还将为3T纯头部MRI扫描仪开发fMRI、解剖MRI、DT-MRI和扩散跟踪方法，以利用该系统的更高性能。这些方法将提供给有特殊需要的项目，当方法得到充分测试并记录下性能改进时，可以在实验中使用。

We propose to maintain and refine magnetic resonance (MR) methods for functional brain imaging (fMRI), anatomical imaging, diffusion tensor imaging (DT-MRI, including imaging of isotropic diffusion and diffusion anisotropy), and DT-MRI based tracking of neuronal fiber pathways. This core will provide a consistent and reliable set of tools throughout the Program, Project Grant period for study of brain function and structure in the normal and ischemic human brain, and for characterizing ischemic brain lesions. These tools will facilitate comparison of MR data within and across experiments and across the three Projects. During the grant period, fMRI, anatomical MRI, DT-MRI, and diffusion tracking methods will also be developed for the 3T head-only MRI scanner to utilize the higher performance of this system. These methods will be made available to the Projects for use in experiments having specialized needs when methods are fully tested and performance improvements are documented.