Core--MR Methods for Functional and Physiologic Imaging

我们建议维持和完善磁共振（MR）方法的功能性脑成像（fMRI），解剖成像，扩散张量成像（DT-MRI，包括成像的各向同性扩散和扩散各向异性），和DT-MRI为基础的神经纤维通路的跟踪。该核心将在整个计划和项目资助期间提供一套一致和可靠的工具，用于研究正常和缺血人脑的脑功能和结构，以及表征缺血性脑病变。这些工具将有助于比较实验内部和实验之间以及三个项目之间的MR数据。在资助期间，还将为3 T头部MRI扫描仪开发fMRI、解剖MRI、DT-MRI和扩散跟踪方法，以利用该系统的更高性能。这些方法将提供给项目，供在方法得到充分测试和性能改进得到记录后，用于有专门需要的实验。

We propose to maintain and refine magnetic resonance (MR) methods for functional brain imaging (fMRI), anatomical imaging, diffusion tensor imaging (DT-MRI, including imaging of isotropic diffusion and diffusion anisotropy), and DT-MRI based tracking of neuronal fiber pathways. This core will provide a consistent and reliable set of tools throughout the Program, Project Grant period for study of brain function and structure in the normal and ischemic human brain, and for characterizing ischemic brain lesions. These tools will facilitate comparison of MR data within and across experiments and across the three Projects. During the grant period, fMRI, anatomical MRI, DT-MRI, and diffusion tracking methods will also be developed for the 3T head-only MRI scanner to utilize the higher performance of this system. These methods will be made available to the Projects for use in experiments having specialized needs when methods are fully tested and performance improvements are documented.