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TRACKING NEURONAL FIBERS IN LIVING HUMAN BRAIN BY MRI

通过 MRI 追踪活人大脑中的神经纤维

基本信息

批准号：
6837653
负责人：
THOMAS EDWARD CONTURO
金额：
$ 41.11万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-01-27 至 2007-12-31
项目状态：
已结题

项目摘要

We propose to extend our developments with magnetic resonance imaging (MRI) for tracking neuronal fibers in the lining human brain. The method, called diffusion tensor tracking (DTT), reconstructs continuous threedimensional trajectories of neuronal fiber bundles from diffusion tensor-encoded MRI data (DT-MRI). Compared to other methods, the MR procedure is non-invasive, capable of studying connectional anatomy unique to humans, and amenable to direct correlation with fMRI activations in the same individual subjects, which potentially will uncover the neuronal connections used for human tasks. Noninvasive DTT methods are especially important for revealing connections in humans associated with cognitive functions like language that cannot be extrapolated from non-human primate studies. For Aim I we will further enhance current computations of three- dimensional whole-brain fiber trajectories from DT-MRI data and develop and refine methods for selecting different fiber groups, especially including connections between regions defined by fMRI. For Aim II we will evaluate the accuracy and precision of DTT fiber trajectories by computer simulation and test-retest evaluation of experimental data. In Aim III we will assess the ability of DTT to determine the connectivity between fMRI-defined primary sensory and higher-order regions in the somatosensory and visual systems using known monkey neuroanatomy as a standard. The visual studies will involve retinotopic fMRI mapping to identify higher visual areas and to select functional subsets of the geniculocalcarine tract, and motion perception studies to activate remote cognitive regions outside the visual cortex. For Aim IV we will examine the potential clinical utility of DTT to characterize the functional effects of white matter lesions by correlating the lesion-to-cortex DTT projections with cortical defects in retinotopic fMRI and with visual field defects in patients with focal lesions of the geniculocalcarine tract. In Aim V, we will compare visual cortex connections in sighted, early- and late-blind subjects to assess the effects of age of blindness on the development and organization of the visual system. Successful completion of the proposed research will provide a set of tested tools for interrogating the development, functional organization, and reorganization of the human brain in normal and disease.

我们建议扩展我们的发展与磁共振成像（MRI）跟踪神经元纤维在内衬人脑。该方法被称为扩散张量跟踪（DTT），通过扩散张量编码的MRI数据（DT-MRI）重建神经元纤维束的连续三维轨迹。与其他方法相比，MR程序是非侵入性的，能够研究人类特有的连接解剖学，并且可以与同一个体受试者的fMRI激活直接相关，这可能会揭示用于人类任务的神经元连接。非侵入性DTT方法对于揭示人类与语言等认知功能相关的联系尤其重要，这些联系无法从非人类灵长类动物的研究中推断出来。对于Aim I，我们将进一步增强当前基于DT-MRI数据的三维全脑纤维轨迹的计算，并开发和改进选择不同纤维组的方法，特别是包括fMRI定义的区域之间的连接。在第二阶段，我们将通过计算机模拟和实验数据的重测评估来评估DTT光纤轨迹的准确性和精度。在Aim III中，我们将使用已知的猴子神经解剖学作为标准，评估DTT确定fmri定义的初级感觉和体感和视觉系统中高阶区域之间连接的能力。视觉研究将包括视网膜定位fMRI映射，以识别更高的视觉区域和选择geniculocaline束的功能亚群，以及运动感知研究，以激活视觉皮层外的远程认知区域。在Aim IV中，我们将研究DTT的潜在临床应用，通过将病变到皮层的DTT投影与视网膜定位功能磁共振成像中的皮层缺陷和先天性局部乳糜管局灶性病变患者的视野缺陷联系起来，来表征白质病变的功能影响。在Aim V中，我们将比较视力正常、早期失明和晚期失明受试者的视觉皮层连接，以评估失明年龄对视觉系统发育和组织的影响。本研究的成功完成将为研究人脑在正常和疾病状态下的发育、功能组织和重组提供一套行之有效的工具。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Brain structure and cognitive correlates of body mass index in healthy older adults.

DOI：
10.1016/j.bbr.2014.10.010
发表时间：
2015-02-01
期刊：
BEHAVIOURAL BRAIN RESEARCH
影响因子：
2.7
作者：
Bolzenius, Jacob D.;Laidlaw, David H.;Cabeen, Ryan P.;Conturo, Thomas E.;McMichael, Amanda R.;Lane, Elizabeth M.;Heaps, Jodi M.;Salminen, Lauren E.;Baker, Laurie M.;Scott, Staci E.;Cooley, Sarah A.;Gunstad, John;Paul, Robert H.
通讯作者：
Paul, Robert H.

Fiber bundle length and cognition: a length-based tractography MRI study.

DOI：
10.1007/s11682-014-9334-8
发表时间：
2015-12
期刊：
BRAIN IMAGING AND BEHAVIOR
影响因子：
3.2
作者：
Behrman-Lay, Ashley M.;Usher, Christina;Conturo, Thomas E.;Correia, Stephen;Laidlaw, David H.;Lane, Elizabeth M.;Bolzenius, Jacob;Heaps, Jodi M.;Salminen, Lauren E.;Baker, Laurie M.;Cabeen, Ryan;Akbudak, Erbil;Luo, Xi;Yan, Peisi;Paul, Robert H.
通讯作者：
Paul, Robert H.

Regional age differences in gray matter diffusivity among healthy older adults.

健康老年人的灰质扩散率的区域年龄差异。

DOI：
10.1007/s11682-015-9383-7
发表时间：
2016-03
期刊：
Brain imaging and behavior
影响因子：
3.2
作者：
Salminen LE;Conturo TE;Laidlaw DH;Cabeen RP;Akbudak E;Lane EM;Heaps JM;Bolzenius JD;Baker LM;Cooley S;Scott S;Cagle LM;Phillips S;Paul RH
通讯作者：
Paul RH

Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review.