Core--MR Methods for Functional and Physiologic Imaging

核心--功能和生理成像的MR方法

• 批准号: 6573415
• 负责人: THOMAS EDWARD CONTURO
• 金额: $ 28.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6573415
• 关键词: bioimaging /biomedical imaging; biomedical facility; cerebral ischemia /hypoxia; clinical research; functional magnetic resonance imaging; human subject; method development

We propose to maintain and refine magnetic resonance (MR) methods for functional brain imaging (fMRI), anatomical imaging, diffusion tensor imaging (DT-MRI, including imaging of isotropic diffusion and diffusion anisotropy), and DT-MRI based tracking of neuronal fiber pathways. This core will provide a consistent and reliable set of tools throughout the Program, Project Grant period for study of brain function and structure in the normal and ischemic human brain, and for characterizing ischemic brain lesions. These tools will facilitate comparison of MR data within and across experiments and across the three Projects. During the grant period, fMRI, anatomical MRI, DT-MRI, and diffusion tracking methods will also be developed for the 3T head-only MRI scanner to utilize the higher performance of this system. These methods will be made available to the Projects for use in experiments having specialized needs when methods are fully tested and performance improvements are documented.

我们建议维持和完善磁共振（MR）方法用于脑功能成像（fMRI）、解剖成像、扩散张量成像（DT-MRI，包括各向同性扩散成像和扩散各向异性成像）以及基于DT-MRI的神经元纤维通路跟踪。该核心将在整个计划和项目资助期间提供一套一致和可靠的工具，用于研究正常和缺血人脑的脑功能和结构，以及缺血性脑病变的特征。这些工具将有助于比较实验内部和实验之间以及三个项目之间的MR数据。在拨款期间，fMRI、解剖MRI、DT-MRI和扩散跟踪方法也将用于3T头部MRI扫描仪，以利用该系统的更高性能。这些方法将提供给项目，以便在有特殊需求的实验中使用，当方法经过充分测试并记录了性能改进时。