ALPHA TOCOPHEROL EFFECT ON MONOCYTES IN RELATION TO ATHEROGENESIS

已有大量数据支持氧化型低密度脂蛋白(Ox-LDL)在 动脉粥样硬化的发病机制。它已被证明能促进 单核细胞趋化，并被巨噬细胞清道夫受体摄取 导致胆固醇酯化。氧化型低密度脂蛋白具有细胞毒性，可能 加速动脉粥样硬化病变的发展。所有的主要细胞 动脉壁(平滑肌细胞、内皮细胞、单核细胞)可以 氧化低密度脂蛋白。看来，呼吸爆发对 活化的单核细胞氧化低密度脂蛋白导致其细胞毒性。 低密度脂蛋白在体内氧化的机制尚不清楚。 抗氧化剂，如生育酚，能够减少 低密度脂蛋白对氧化的敏感性。目前尚不清楚抗氧化剂如何 影响体内可氧化低密度脂蛋白的动脉壁细胞。不是 到目前为止发表的研究已经检验了抗氧化剂的作用。 补充动脉壁细胞，如单核细胞和 因此，本研究的目的是测试其对血管内皮细胞的影响 补充α-生育酚对单核细胞功能的影响 对脂质过氧化和动脉粥样硬化，因为它是最容易的 动脉壁中可供研究的细胞。

Much data have accrued supporting the role of oxidized LDL(Ox-LDL) in the pathogenesis of atheroschlerosis. It has been shown to promote monocyte chemotaxis and is taken up by the macrophage scavenger receptor resulting in cholesterol esterification. Ox-LDL is cytotoxic and may hasten development of the atherosclerotic lesion. All major cells of the artery wall (smooth muscle cells, endothelial cells, monocytes) can oxidize LDL. It appears that the respiratory burst is important for the oxidation of LDL by activated monocytes resulting in its cytotoxicity. The mechanism of LDL oxidation in vivo remains to be elucidated. Antioxidants such as alpha tocopherol are able to reduce the susceptibility of LDL to oxidation. It is unknown how antioxidants can affect the cells of the artery wall that can oxidize LDL in vivo. No studies published to date have examined the effect of antioxidant supplementation on the cells of the arterial wall, such as monocytes and endothelial cells.Hence, it is the aim of the study to test the effect of alpha tocopherol supplementation on monocyte function as it relates to lipid peroxidation and atherogenesis, since it is the most readily available cell in the arterial wall for study.