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ENDOCRINE ASPECTS OF HIV INFECTION

ENDOCRINE ASPECTS OF HIV INFECTION
HIV 感染的内分泌方面
批准号:
6305623
负责人:
MORRIS SCHAMBELAN
金额:
$0.06万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-12-01 至 2000-11-30

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中文摘要
翻译
随着HIV感染,垂体、肾上腺和性腺激素会发生各种变化,似乎与疾病的进展有关。患者将接受垂体-肾上腺、性腺和生长激素轴的评估,特别关注昼夜节律和对下丘脑释放激素的反应。这项研究的目的是描述与艾滋病毒感染相关的内分泌变化,并将这些发现与疾病状态和免疫状态相关联。患者还将在开始有效的抗病毒或免疫调节治疗(如蛋白酶抑制剂、沙利度胺)之前和之后进行前瞻性评估,以评估这些药物对激素环境的影响。
英文摘要
Various alterations in pituitary, adrenal and gonadal hormones occur with HIV infection and appear to correlate with disease progression. Patients will be evaluated for pituitary-adrenal, gonadal and growth hormone axes, with specific attention to circadian rythmicity and response to hypothalamic-releasing hormones. The goal of this study is to characterize the endocrine changes associated with HIV infection and to correlate these findings with disease state and immune status. Patients will also be evaluated prospectively before and after initiation of potent antiviral or immunomodulatory therapy (e.g. protease inhibitors, thalidomide) to assess the impact of these agents on the hormonal milieu.
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DEVELOPMENT OF APPROPRIATE CORONARY HEART DISEASE RISK PREDICTION MODELS
  • 批准号:
    8168765
  • 项目类别:
  • 资助金额:
    $1.23万
  • 财政年份:
    2010
  • 负责人:
    MORRIS SCHAMBELAN
  • 依托单位:
DEVELOPMENT OF APPROPRIATE CORONARY HEART DISEASE RISK PREDICTION MODELS
  • 批准号:
    7954018
  • 项目类别:
  • 资助金额:
    $0.38万
  • 财政年份:
    2009
  • 负责人:
    MORRIS SCHAMBELAN
  • 依托单位:
Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV
Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV
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