3rd Intl Symp on Serpin Biology, Structure and Function

描述（由申请人提供）：第三次请求部分支持 丝氨酸蛋白酶抑制剂的生物学、结构和功能国际研讨会， 2002年6月2日至5日在伊利诺斯州的芝加哥举行。本次会议将是第三届 来自世界各地的基础和临床科学家三年一度的聚会， 专门和唯一地关注被称为丝氨酸蛋白酶抑制剂的蛋白质超家族。 这是一个快速发展的领域，得到了研究赠款的大力支持 尤其是NHLBI和NCI。前几次会议是在 1996年在查佩尔山的北卡罗来纳州大学， 1999年，英国剑桥。本次会议将由 伊利诺伊大学芝加哥分校。重点将放在 正常形式和变体形式的丝氨酸蛋白酶抑制剂的基本性质之间的关系， 这些与正常人类生理过程和疾病之间的关系。十 会议将讨论基本的结构和机制问题， 丝氨酸蛋白酶抑制剂功能或丝氨酸蛋白酶抑制剂在正常和疾病状态中的参与。34 特邀演讲者将来自四大洲，代表各领域的专家， 领域24个额外的简短演讲（10分钟加5分钟的讨论）将在 从提交的摘要中选出，以提供更多机会， 年轻的科学家来展示他们的工作。还将举行两次海报会议。 预计约有200名科学家将出席会议。这些将 包括两个博士学位。和医学博士研究人员，无论是基础还是应用， 以疾病为导向的观点、兴趣和专业知识。以这种方式组织起来， 会议预计将实现以下目标：（一）提供一个 将基础科学家聚集在一起讨论serpin功能的地点 不同的组织级别，以更好地联系serpin结构的作用 和生理行为的机制。(ii)将基本的 科学家和临床科学家，以确定丝氨酸蛋白酶抑制剂的作用， 和病理人类条件，以促进治疗的发展， 依赖于对基本丝氨酸蛋白酶抑制剂的理解的诊断测试和治疗 功能(iii)为与会者提供有关serpin的最新信息 作用机制和参与正常和异常的生理 通过包括许多从提交的摘要中选择的简短演讲， 除了早先选定的主要会谈之外。(iv)为所有参与者提供 有很多机会与演讲者和海报进行深入讨论 演讲者，以学科之间的交叉施肥为目标， 鼓励合作。(v)为承诺提供机会 青年科学家和少数民族在会议中发挥重要作用。

DESCRIPTION (provided by applicant): Partial support is requested for the 3rd International Symposium on the biology, structure, and function of serpins, to be held in Chicago, Illinois June 2-5, 2002. This conference will be the third triennial gathering of basic and clinical scientists from around the world to focus specifically and solely on the superfamily of proteins known as serpins. This is a rapidly-growing area that is heavily supported by research grants from NIH, particularly NHLBI and NCI. Previous meetings were held at the University of North Carolina, Chapel Hill in 1996, and at the University of Cambridge, England in 1999. The present meeting will be sponsored by the University of Illinois at Chicago. The emphasis will be on the relationship between the basic properties of serpins in both normal and variant forms and how these relate to both normal human physiological processes and disease. Ten sessions will address either basic structural and mechanistic questions of serpin function or the involvement of serpins in normal and disease states. 34 invited speakers will be from four continents and represent experts in the field. 24 additional short talks (10 minutes plus 5 minutes discussion) will be selected from submitted abstracts to provide additional opportunities for junior scientists to present their work. Two poster sessions will also be held. It is expected that about 200 scientists will attend the meeting. These will include both Ph.D. and M.D. researchers, with both basic and applied, disease-oriented perspectives, interests and expertise. Organized in this way, the conference is expected to accomplish the following goal (i) To provide a venue for bringing together basic scientists addressing serpin function at different organizational levels to better relate the roles of serpin structure and mechanism to physiological behavior. (ii) To bring together basic scientists and clinical scientists to identify the roles of serpins in normal and pathological human conditions to foster development of therapeutics, diagnostic tests and treatments that depend on understanding of basic serpin function. (iii) To provide participants with the latest information on serpin mechanisms of action and involvement in normal and abnormal physiological processes by including many short talks selected from submitted abstracts, in addition to the earlier-selected main talks. (iv) To provide all participants with many opportunities for in-depth discussion with speakers and poster presenters, with the goal of cross-fertilization between disciplines and encouragement of collaborations. (v) To provide an opportunity for promising junior scientists and minorities to play a major role in the meeting.