Blood-Brain-CSF Barriers, CNS Homeostasis, Drug Delivery

血脑脑脊液屏障、中枢神经系统稳态、药物输送

• 批准号: 6550284
• 负责人: Martha E O'Donnell
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550284
• 关键词: blood brain barrier; brain; central nervous system; drug delivery systems; homeostasis; meeting /conference /symposium; travel

This proposal is a request for funds toward the support of a Gordon Research Conference to be held in July 2002. The intended meeting is the second Gordon Research Conference on Barriers of the Central Nervous System. This Gordon Research Conference was initiated as a catalyst for interaction among researchers from a variety f disciplines working on issues of blood-brain- and blood-CSF barriers in health disease. Research in this area is already leading to development of new therapeutic approaches for th treatment of stroke, head trauma, neurodegeneration, brain inflammation and brain tumors, to name a fe3w. Although portions of these areas of investigation are represented at several national and international research meetings, there have been few opportunities for scientists working in the field to come together with a specific concentrated focus on issues related to barriers of the CNS. The subtitle of the upcoming second Barriers of the CNS Gordon Research Conference is "Blood-Brain CSF barriers, CNS Homeostasis and Drug Delivery to the Brain". The specific focus of this conference will include discussion of a number of the problems and tissues faced by the Pharmaceutical industry in targeting therapeutic drugs to the CNS as well as discussion of broader current major developments of the blood- brain-barrier and blood-CSF barrier field. Most of these problems concern overcoming the blood-brain barrier to drugs. To this end a number of eminent scientists from academia and from the pharmaceutical industry, are being brought together for an exciting "leading edge" meeting. The intention is to foster the development of new ideas and their application to fundamental knowledge and the treatment of human and animal disease. Speakers have been selected on the basis of their eminence in the field and their communication skills. TO this end they are drawn from a wide geographical background. Chairs of the sessions have been selected on the basis of their considerable eminence and experience in the field and a known ability to communicate and debate well. In addition the presentation of posters is being vigorously encouraged especially by young postdoctoral and research students. It is expected that a considerable proportion of any NIH grant will be used to fund the attendance of young scientists and chairs. It is also intended to have three open workshops/debates during the meeting. One is already in place on "Microdialysis". The maximum permitted attendance at this meeting is 150 scientists.

这项建议是为支持将于2002年7月举行的戈登研究会议而提出的资金请求。计划召开的会议是关于中枢神经系统障碍的第二届戈登研究会议。戈登研究会议是作为来自不同学科的研究人员之间互动的催化剂发起的，这些研究人员致力于健康疾病中的血-脑-和血-脑脊液屏障问题。这一领域的研究已经导致开发新的治疗方法，用于治疗中风、头部创伤、神经退行性变、脑部炎症和脑肿瘤，举个例子。尽管这些研究领域的一部分代表参加了几次国家和国际研究会议，但该领域的科学家很少有机会聚集在一起，具体集中于与中枢神经系统障碍有关的问题。即将召开的CNS戈登研究大会第二道屏障的副标题是《血脑脊液屏障、中枢神经系统稳态与药物脑内给药》。这次会议的具体焦点将包括讨论制药业在针对中枢神经系统的治疗药物方面所面临的一些问题和组织，以及讨论血脑屏障和血-脑脊液屏障领域目前更广泛的主要发展。这些问题中的大多数都涉及克服药物的血脑屏障。为此，许多来自学术界和制药业的杰出科学家将汇聚一堂，参加一次令人兴奋的“前沿”会议。其目的是促进新思想的发展，并将其应用于基础知识和人类和动物疾病的治疗。发言者是根据他们在实地的显赫地位和沟通技巧挑选出来的。为此，他们来自广泛的地理背景。各届会议主席的遴选依据是他们在实地具有相当大的知名度和经验，以及众所周知的良好沟通和辩论能力。此外，正在大力鼓励张贴海报，特别是年轻的博士后和研究生。预计NIH拨款中的相当大一部分将用于资助年轻科学家和教席的出席。它还打算在会议期间举办三个公开讲习班/辩论。其中一项关于“微透析”的研究已经到位。这次会议允许的最大出席人数是150名科学家。