2004 Barriers of CNS

描述（由申请人提供）：本申请为将于2004年6月27日至7月2日在新罕布什尔州蒂尔顿举行的第三届“中枢神经系统障碍”戈登研究会议申请资金。还要求为将于2006年和2008年举行的第四次和第五次会议提供资金支持。这次戈登研究会议的发起是为了促进来自不同学科的研究人员在健康和疾病中的血脑屏障（BBB）和血csf屏障问题上的互动。这一领域的研究已经为中风、头部创伤、神经变性、脑炎和脑肿瘤的治疗提供了新的治疗方法，仅举几例。尽管这些研究领域的一部分在一些国家和国际研究会议上有代表，但在该领域工作的科学家很少有机会聚集在一起，集中关注与中枢神经系统障碍有关的问题。即将召开的2004年会议将包括与血脑屏障和血- csf屏障的生理学和病理生理学以及向中枢神经系统输送药物和基因疗法有关的问题。2004年会议的一个新方面将是考虑神经血管单元和血脑屏障细胞如何在神经环境中与其他细胞相互作用。特别值得注意的是，血脑屏障研究已被美国国立卫生研究院确定为发展的关键领域。与此相一致的是，CNS戈登屏障研究会议的使命是为具有各种背景和经验的科学家提供一个论坛，分享未发表的发现，并共同确定新的策略，以解决有关血脑屏障和血/CSF屏障的许多尚未解决的问题。为此，来自学术界和制药业的著名科学家齐聚一堂，召开一次激动人心的“前沿”会议。发言者的选择是根据他们在该领域的杰出地位和他们的沟通技巧。它们有着广泛的地理背景。这些会议的主席是根据他们在该领域相当显赫的地位和经验以及众所周知的良好沟通和辩论能力来选择的。此外，海报的展示也受到大力鼓励，特别是年轻的博士后和研究生。预计任何NIH拨款的相当一部分将用于资助年轻科学家和主席的出席。还计划在会议期间举行两次公开讲习班/辩论。这次会议最多允许150名科学家出席。

DESCRIPTION (provided by applicant): This proposal is a request for funds toward support of the 3rd "Barriers of the CNS" Gordon Research Conference to be held June 27th to July 2nd 2004 in Tilton, NH. Funds are also requested for support of the 4th and 5th conferences, to be held in 2006 and 2008. This Gordon Research Conference was initiated as a catalyst for interaction among researchers from a variety of disciplines working on issues of blood-brain-barrier (BBB) and blood-CSF barrier in health and disease. Research in this area is already leading to development of new therapeutic approaches for the treatment of stroke, head trauma, neurodegeneration, brain inflammation and brain tumors, to name a few. Although portions of these areas of investigation are represented at several national and international research meetings, there have been few opportunities for scientists working in the field to come together with a specific concentrated focus on issues related to barriers of the CNS. The upcoming 2004 conference will include issues related to the physiology and pathophysiology of the BBB and blood-CSF barriers as well as the delivery of drug and gene therapies to the CNS. A new aspect of the 2004 meeting will be consideration of the neurovascular unit and how BBB cells interact with other cells in the neural environment. It is especially noteworthy that blood-brain barrier research has been identified by NIH as a critical area for development. Consistent with this, the mission of the Barriers of the CNS Gordon Research Conferences is to provide a forum for scientists with a variety of backgrounds and experience to share unpublished findings and work together to identify new strategies for attacking the many remaining unanswered questions with respect to the BBB and blood/CSF barriers. To this end, eminent scientists from both academia and the pharmaceutical industry are being brought together for an exciting "leading edge" meeting. Speakers have been selected on the basis of their eminence in the field and their communication skills. They are drawn from a wide geographical background. Chairs of the sessions have been selected on the basis of their considerable eminence and experience in the field and a known ability to communicate and debate well. In addition the presentation of posters is being vigorously encouraged especially by young postdoctoral and research students. It is expected that a considerable proportion of any NIH grant will be used to fund the attendance of young scientists and chairs. Two open workshops/debates to occur during the meeting are also planned. The maximum permitted attendance at this meeting is 150 scientists.