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Investigating how plants recruit antibiotic-producing Streptomyces bacteria to protect themselves against disease

研究植物如何招募产生抗生素的链霉菌来保护自己免受疾病侵害

基本信息

批准号：
1799823
负责人：
金额：
--
依托单位：
University of East Anglia
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1799823
关键词：
Investigating how plants recruit antibiotic

项目摘要

Humans have been using antibiotics to treat disease for less than 100 years but their use in nature stretches back for tens of millions of years. Most of the antibiotics we use are made by a group of common soil bacteria called Streptomyces and plants and insects started using them long before humans. Plants including the model Arabidopsis thaliana and important food crops like wheat, potato and rice, all have Streptomyces living inside their roots. Indeed, several recent high profile papers have shown that Streptomyces bacteria are enriched in the rhizosphere (the soil coating the roots) and even more greatly enriched inside the roots of Arabidopsis compared to the surrounding soil. Research published in Science in August 2015 suggests that Streptomyces bacteria are specifically attracted by salicylic acid (SA) that is produced by the plants as part of their general stress response. The suggestion is that Streptomyces (but not all bacteria) can use SA as a food source and thus the plants can specifically select bacteria that are useful to them out of the trillions of bacteria present in the soil. The antibiotics made by these Streptomyces strains are thought to protect the plant roots against fungal infection. In this project we will use Arabidopsis as a model to test (1) if Streptomyces bacteria in the rhizosphere and roots are really using plant-produced SA as food, (2) if any and all Streptomyces strains can live inside plant roots, (3) if SA metabolism is essential for root colonisation by Streptomyces and (4) if Streptomyces-produced antifungals do indeed protect the plants against fungal infection. Ultimately this work will lay the foundation for engineering improved Streptomyces strains for use in agriculture and thus contribute to global food security.

人类使用抗生素治疗疾病不到100年，但它们在自然界中的使用可以追溯到数千万年前。我们使用的大多数抗生素是由一组名为链霉菌的常见土壤细菌制造的，植物和昆虫早在人类之前就开始使用它们。包括拟南芥模型在内的植物，以及小麦、土豆和水稻等重要粮食作物，都有链霉菌生活在它们的根部。事实上，最近几篇备受瞩目的论文表明，链霉菌在根际(覆盖根部的土壤)中富含，与周围土壤相比，拟南芥根部内的富集度更高。2015年8月发表在《科学》杂志上的研究表明，链霉菌特别被水杨酸(SA)吸引，水杨酸是植物作为一般压力反应的一部分。建议是链霉菌(但不是所有的细菌)可以利用SA作为食物来源，因此植物可以从土壤中存在的数万亿细菌中专门选择对它们有用的细菌。这些链霉菌菌株制造的抗生素被认为可以保护植物的根不受真菌感染。在这个项目中，我们将使用拟南芥作为模型来测试(1)根际和根中的链霉菌是否真的以植物产生的SA为食物，(2)是否有任何和所有的链霉菌菌株可以生活在植物根内，(3)SA代谢是否对链霉菌的根定植至关重要，以及(4)链霉菌产生的抗真菌药物是否真的保护植物免受真菌感染。最终，这项工作将为设计用于农业的改良链霉菌菌株奠定基础，从而为全球粮食安全做出贡献。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Streptomyces endophytes promote the growth of Arabidopsis thaliana

DOI：
10.1101/532309
发表时间：
2019-01
期刊：
bioRxiv
影响因子：
0
作者：
Sarah F. Worsley;J. Newitt;Johannes Rassbach;S. Batey;Neil A. Holmes;J. Murrell;B. Wilkinson;M. Hu
通讯作者：
Sarah F. Worsley;J. Newitt;Johannes Rassbach;S. Batey;Neil A. Holmes;J. Murrell;B. Wilkinson;M. Hu