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PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH

心源性猝死的心理社会因素

基本信息

批准号：
6529350
负责人：
SUE A THOMAS
金额：
$ 24.4万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-30 至 2005-08-31
项目状态：
已结题

项目摘要

This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)." The PFOS study will 1) assess psychosocial (Psychological: anxiety, depression; social: social support, pet ownership, life stress) status of 300 patients enrolled in the SCD-HeFT clinical trial at baseline, after one month, and every six months for 2 years; 2) investigate the independent contributions of baseline psychosocial factors to survival of heart patients (HF) patients; 3) evaluate the impact of implanted cardioverter defibrillators (ICD) on the psychosocial status of heart failure (HF) patients who receive ICD as primary prevention for sudden cardiac death (SCD); and 4) compare the psychosocial impact of ICD with the impact of the other HF treatments. The SCD-HeFT, primary prevention trial, is designed to compare the effectiveness of three randomly assigned treatments in improving survival for patients with HF. The three treatments are: conventional therapy of HF and placebo, conventional therapy of HF and Amiodarone, and conventional therapy of HF and ICD. PFOS will utilize SCD-HeFT physiological and demographic data. Specific hypotheses will be tested with a minimum power of .8, using logistic multiple regression, linear multiple regression, chi-square, and multivariate analysis of variance. Heart failure affects 1-2 million people in the United States. As mortality from myocardial infarction has decreased due to improved treatment, the number of people living with HF has increased. Over half of the deaths from HF are due to SCD. The results of the PFOS have potential to influence nursing practice, save lives of HF patients, and prevent escalated health care costs as HF progresses. Nursing plays a major therapeutic role in the management of cardiac patients and their families. It is imperative to target interventions to maximize effectiveness at decreasing mortality and morbidity. The PFOS will identify a high-risk profile for HF patients. Using this profile, nurses can identify patients at greatest risk and develop interventions to modify the forms of psychosocial distress, which specifically contribute to SCD and long term psychosocial distress. The combination of data from PFOS and SCD-HeFT will provide a holistic assessment of HF patients.

本提案“突发性心脏病患者的心理社会因素结局研究死亡（全氟辛烷磺酸）”是一个独立的项目，美国国立卫生研究院临床试验，“心脏性猝死心力衰竭试验（SCD-HeFT）。“那全氟辛烷磺酸研究将：1）评估社会心理（心理：焦虑、抑郁; 社会：社会支持，宠物所有权，生活压力）状态的300名患者在基线时、一个月后和每一个月后， 6个月，为期2年; 2）调查基线心理社会因素对心脏病患者（HF）生存率的影响; 3）评价植入式心律转复除颤器（ICD）对接受ICD作为主要治疗的心力衰竭（HF）患者的心理社会状况预防心源性猝死（SCD）; 4）比较 ICD的影响与其他HF治疗的影响。SCD-HeFT，初级预防试验，旨在比较三种随机分配治疗以改善HF患者的生存率。三治疗是：HF和安慰剂的常规治疗， HF和胺碘酮，以及HF和ICD的常规治疗。全氟辛烷磺酸将利用 SCD-HeFT生理和人口统计数据。将检验具体假设最小功效为.8，使用逻辑多元回归，线性多元回归回归、卡方和多变量方差分析。心力衰竭影响了美国1-2百万人。由于心肌梗死由于治疗方法的改善，脑梗死的人数有所减少， HF增加了。超过一半的HF死亡是由于SCD。的全氟辛烷磺酸的结果有可能影响护理实践，挽救生命， HF患者，并防止随着HF进展而增加的医疗保健费用。护理在心脏病患者的管理中起着重要的治疗作用，家庭必须有针对性地采取干预措施，以最大限度地发挥效力，降低死亡率和发病率。全氟辛烷磺酸将确定高风险概况 HF患者。使用此配置文件，护士可以最大限度地识别患者风险和制定干预措施，以改变心理社会困扰的形式，这特别有助于SCD和长期的心理社会困扰。的将全氟辛烷磺酸和SCD-HeFT的数据结合起来， HF患者。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Depression in patients with heart failure: physiologic effects, incidence, and relation to mortality.

心力衰竭患者的抑郁：生理影响、发生率以及与死亡率的关系。

DOI：
10.1097/00044067-200302000-00002
发表时间：
2003
期刊：
AACN clinical issues
影响因子：
0
作者：
Thomas,SueAnn;Friedmann,Erika;Khatta,Meenakshi;Cook,LindaK;Lann,AnitaLippman
通讯作者：
Lann,AnitaLippman

Depression in patients with heart failure: prevalence, pathophysiological mechanisms, and treatment.

心力衰竭患者的抑郁：患病率、病理生理机制和治疗。

DOI：
发表时间：
2008
期刊：
Critical care nurse
影响因子：
1.6
作者：
Thomas,SueA;Chapa,DeborahWince;Friedmann,Erika;Durden,Cheryl;Ross,Alyson;Lee,MeiChingY;Lee,Hyeon-Joo
通讯作者：
Lee,Hyeon-Joo

Quality of life and psychological status of patients with implantable cardioverter defibrillators