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MOLECULAR GENETICS OF HYPERTENSION

MOLECULAR GENETICS OF HYPERTENSION
高血压的分子遗传学
批准号：
6306674
负责人：
LESLIE RAFFEL
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6306674
关键词：
Mexican Americans cell line clinical research familial hypertension family genetics gene expression human genetic material tag human subject insulin sensitivity /resistance molecular genetics phenotype tissue /cell culture tissue /cell preparation

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中文摘要
翻译
目的是确定影响血压的基因，从而确定墨西哥裔美国人家庭中高血压的发病原因。由于胰岛素抵抗在高血压中的重要性，以及墨西哥裔美国人中胰岛素抵抗的高患病率，本研究非常重视胰岛素抵抗作为该种族群体的中间表型的检查。患者在南加州大学招募，用于DNA研究的淋巴母细胞样细胞系在雪松西奈的组织培养设施中建立。
英文摘要
The goal is to identify genes which influence blood pressure and thus are responsible for the development of hypertension in Mexican American families. Because of the importance of insulin resistance in hypertension, as well as the high prevalence of insulin resistance in the Mexican American population, the study places great emphasis on examination of insulin resistance as an intermediate phenotype in this ethnic group. Patients are recruited at USC and lymphoblastoid cell lines for DNA studies are established in the Tissue Culture Facility here at Cedars-Sinai.
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会议论文
GENNID--NIDDM FAMILY ACQUISITION CENTER
GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS
MOLECULAR GENETICS OF HYPERTENSION
DIABETES PREVENTION TRIAL-TYPE 1 DIABETES (DPT-1)
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