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GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS

GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS
NIDDM 与动脉粥样硬化之间的遗传关系
批准号：
6306669
负责人：
LESLIE RAFFEL
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6306669
关键词：
Hispanic Americans atherosclerosis clinical research coronary artery coronary disorder disease /disorder proneness /risk family genetics genetic disorder human genetic material tag human subject noninsulin dependent diabetes mellitus tissue /cell culture

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中文摘要
翻译
尽管患有非胰岛素依赖型糖尿病（NIDDM）的人患冠状动脉疾病的风险明显更高，而且NIDDM在西班牙裔美国人中发病率更高，但与非西班牙裔白人糖尿病患者相比，该人群发生动脉粥样硬化的几率要小得多。这一观察结果的遗传基础正在有冠状动脉疾病和无冠状动脉疾病的西班牙裔NIDDM患者的家庭中进行测试。在组织培养设施中建立了用于DNA研究的淋巴母细胞样细胞系。
英文摘要
Although individuals with noninsulin dependent diabetes mellitus (NIDDM) have a significantly higher risk for coronary artery disease and NIDDM occurs with increased frequency in Hispanic Americans, the occurrence of atherosclerosis is much less in this group than in non Hispanic Caucasian diabetic individuals. The genetic basis for this observation is being tested in the families of Hispanic NIDDM patients with and without coronary disease. Lymphoblastoid cell lines are established for DNA studies in the Tissue Culture Facility.
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会议论文
GENNID--NIDDM FAMILY ACQUISITION CENTER
GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS
MOLECULAR GENETICS OF HYPERTENSION
DIABETES PREVENTION TRIAL-TYPE 1 DIABETES (DPT-1)
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