GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS

NIDDM 与动脉粥样硬化之间的遗传关系

• 批准号: 6306669
• 负责人: LESLIE RAFFEL
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6306669
• 关键词: Hispanic Americans; atherosclerosis; clinical research; coronary artery; coronary disorder; disease /disorder proneness /risk; family genetics; genetic disorder; human genetic material tag; human subject; noninsulin dependent diabetes mellitus; tissue /cell culture

Although individuals with noninsulin dependent diabetes mellitus (NIDDM) have a significantly higher risk for coronary artery disease and NIDDM occurs with increased frequency in Hispanic Americans, the occurrence of atherosclerosis is much less in this group than in non Hispanic Caucasian diabetic individuals. The genetic basis for this observation is being tested in the families of Hispanic NIDDM patients with and without coronary disease. Lymphoblastoid cell lines are established for DNA studies in the Tissue Culture Facility.

尽管非胰岛素依赖型糖尿病（NIDDM）患者患冠状动脉疾病的风险显著增高，且NIDDM在西班牙裔美国人中的发生频率增加，但这一人群中动脉粥样硬化的发生率远低于非西班牙裔白人糖尿病患者。 这一观察结果的遗传基础正在西班牙裔NIDDM患者（有或无冠心病）的家族中进行测试。 在组织培养设施中建立淋巴母细胞样细胞系用于DNA研究。