DIABETES PREVENTION TRIAL-TYPE 1 DIABETES (DPT-1)

糖尿病预防试验 1 型糖尿病 (DPT-1)

• 批准号: 6219892
• 负责人: LESLIE RAFFEL
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219892
• 关键词: antibody; clinical research; clinical trials; diabetes mellitus therapy; disease /disorder prevention /control; dosage; family genetics; hormone therapy; human subject; human therapy evaluation; injection /infusion; insulin; insulin dependent diabetes mellitus; pancreatic islets; secretion

This multicenter randomized trial is designed to evaluate the ability of low dose insulin therapy, in association with periodic continuous insulin infusions ('beta cell rest') to delay and/or prevent the development of insulin dependent diabetes in first degree relatives of individuals with IDDM. Nondiabetic, islet cell antibody positive individuals who also have alteraitons in first phase insulin secretion are qualified for randomization.

本多中心随机试验旨在评价低剂量胰岛素治疗联合周期性持续胰岛素输注（“β细胞静息”）延迟和/或预防胰岛素依赖型糖尿病患者一级亲属发生胰岛素依赖型糖尿病的能力。 非糖尿病、胰岛细胞抗体阳性且第一时相胰岛素分泌改变的个体有资格进行随机化。