Bioinformatics tools for the genome-wide analysis of small RNA interaction networks

用于小 RNA 相互作用网络全基因组分析的生物信息学工具

• 批准号: 1802507
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1802507
• 关键词: Bioinformatics; tools; genome; wide; analysis

This project involves the development of cutting-edge bioinformatics tools to analyse small RNAs. The discovery of small RNAs in plants and animals has revolutionised our knowledge gene regulation. However, although much progress has been made on certain small RNAs and their targets (such as microRNAs), very little is known about genome-wide scale small RNA regulatory networks. In this project, the student will work together with a unique combination of world-class experts in bioinformatics, genomics and small RNAs with the aim of identifying, validating and visualising regulatory interaction networks of small RNAs and their target genes. This will build on recent work developed in Moulton's group on genome-wide target identification and validation using the "degradome". In particular, the student will work on developing algorithms and computer programs for visualising and identifying small RNAs regulatory interaction networks in plants with Professors Vincent Moulton and Tamas Dalmay (UEA).

该项目涉及开发用于分析小RNA的尖端生物信息学工具。植物和动物中小RNA的发现彻底改变了我们的基因调控知识。然而，尽管在某些小RNA及其靶标(如microRNAs)方面已经取得了很大进展，但对全基因组范围的小RNA调控网络知之甚少。在这个项目中，学生将与生物信息学、基因组学和小RNA方面的世界级专家的独特组合一起工作，目的是识别、验证和可视化小RNA及其目标基因的调控相互作用网络。这将建立在莫尔顿团队最近开展的利用“降解穹顶”进行全基因组靶标识别和验证的工作基础上。特别是，学生将与文森特·莫尔顿教授和塔马斯·达尔梅教授(UEA)合作开发算法和计算机程序，以可视化和识别植物中的小RNA调控相互作用网络。

项目成果

PAREsnip2: a tool for high-throughput prediction of small RNA targets from degradome sequencing data using configurable targeting rules.

• DOI: 10.1093/nar/gky609
• 发表时间: 2018-09-28
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Thody J;Folkes L;Medina-Calzada Z;Xu P;Dalmay T;Moulton V
• 通讯作者: Moulton V