Genetic analysis of attention deficit hyperactivity dis.

注意缺陷多动症的遗传分析。

• 批准号: 6430094
• 负责人: Maximilian Muenke
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6430094
• 关键词: Hispanic Americans; attention deficit disorder; behavioral genetics; blood chemistry; clinical research; expression cloning; family genetics; gene expression; genetic mapping; human genetic material tag; human subject; linkage mapping; psychological tests; siblings

A study of the hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder will be undertaken through a genome wide search for loci linked to ADHD. To this end, 700 affected sibling pairs and 100 densely affected multi-generation Hispanic families will be recruited. Participating individuals will undergo a battery of psychological tests and will have blood drawn for the linkage analysis and positional cloning studies that will be used to search for genes associated with ADHD.

注意力缺陷多动障碍 (ADHD) 是一种遗传影响的脑部疾病这一假设的研究将通过全基因组搜索与 ADHD 相关的基因座来进行。为此，将招募700对受影响的兄弟姐妹和100个受影响严重的多代西班牙裔家庭。参与的个人将接受一系列心理测试，并抽血进行连锁分析和定位克隆研究，这些研究将用于寻找与多动症相关的基因。