Genetics of Attention Deficit Hyperactivity Disorder

注意力缺陷多动障碍的遗传学

• 批准号: 6830467
• 负责人: Maximilian Muenke
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6830467
• 关键词: Hispanic Americans; attention deficit disorder; biotechnology; blood tests; brain disorders; clinical research; computer simulation; family genetics; generation difference; genetic disorder; genetic screening; genome; human subject; linkage mapping; middle childhood (6-11); psychological tests; siblings

Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. A genome-wide search for loci linked to ADHD has been completed. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage. The next phase of our research on ADHD involves US families with ADHD.

注意力缺陷多动障碍（ADHD）是一种遗传性大脑疾病，在学龄儿童中的患病率为3-5%。受影响的兄弟姐妹对和密集影响的多代西班牙裔家庭已被招募。一个全基因组搜索与多动症相关的基因座已经完成。参与者接受一系列心理测试，并抽血进行连锁分析和定位克隆研究，这些研究被用来寻找与ADHD相关的基因。到目前为止，我们有15个大的，多代西班牙裔家庭的完整信息。对27个信息丰富的家系的模拟研究表明，极好的权力，以检测连锁。我们对ADHD的下一阶段研究涉及美国ADHD家庭。