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Genetics of Attention Deficit Hyperactivity Disorder

Genetics of Attention Deficit Hyperactivity Disorder
注意力缺陷多动障碍的遗传学
批准号：
6830467
负责人：
Maximilian Muenke
金额：
$0.0万
依托单位：
NATIONAL HUMAN GENOME RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6830467
关键词：
Hispanic Americans attention deficit disorder biotechnology blood tests brain disorders clinical research computer simulation family genetics generation difference genetic disorder genetic screening genome human subject linkage mapping middle childhood (6-11) psychological tests siblings

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英文摘要
Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. A genome-wide search for loci linked to ADHD has been completed. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage. The next phase of our research on ADHD involves US families with ADHD.
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Beyond the reproductive tract: The future of Y chromosome research
Beyond the reproductive tract: The future of Y chromosome research
Beyond the reproductive tract: The future of Y chromosome research
GENETIC ANALYSIS OF HUMAN BRAIN DEVELOPMENT
  • 批准号：
    2502634
  • 项目类别：
  • 资助金额：
    $39.77万
  • 财政年份：
    1994
  • 负责人：
    Maximilian Muenke
  • 依托单位：
    CHILDREN'S HOSP OF PHILADELPHIA
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