Catalytic Hydrogenations of Organic and Inorganic C=O Bonds

有机和无机 C=O 键的催化氢化

• 批准号: 1805095
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1805095
• 关键词: Catalytic; Hydrogenations; Organic; Inorganic; C=O

New trialkylstannylium [R3Sn]+ triflates, triflimides, and tetra(fluoroaryl)borates will be synthesised using well-established organotin synthetic chemistry, which allows access to tin hydrides (simple inorganic reductions) and other counterions (salt metathesis). Reactions under catalytic direct hydrogenation conditions (H2, elevated T), with organic carbonyls, esters, and amides will be monitored primarily with 1H and 119Sn NMR. The same tin catalysts will be used for CO reduction, which will also utilise co-catalytic simple transition metal carbonyls [e.g. Fe(CO)5, Co2(CO)8] and will be carried out at 4-150 bar of syngas (CO+H2) 100-200 degrees C; this will be monitored by in situ GC-MS/IR analysis of gas aliquots (collaboration Christopher Tighe, Chem Eng) alongside 1H and 13C NMR spectroscopy of products mixtures.

新的三烷基锡[R3 Sn]+三氟甲磺酸盐、三氟甲酰胺和四（氟芳基）硼酸盐将使用成熟的有机锡合成化学进行合成，这允许获得锡还原（简单的无机还原）和其他抗衡离子（盐复分解）。在催化直接氢化条件下（H2，升高的T），与有机羰基化合物，酯和酰胺的反应将主要用1H和119 Sn NMR监测。相同的锡催化剂将用于CO还原，其也将利用助催化的简单过渡金属羰基化合物[例如Fe（CO）5、Co2（CO）8]，并且将在4-150巴的合成气（CO+H2）100-200 ℃下进行;这将通过气体等分试样的原位GC-MS/IR分析（Christopher Tighe，Chem Eng的合作）以及产物混合物的1H和13 C NMR光谱来监测。

项目成果

Hydrogen activation using a novel tribenzyltin Lewis acid.

• DOI: 10.1098/rsta.2017.0008
• 发表时间: 2017-08-28
• 期刊: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
• 作者: Cooper RT;Sapsford JS;Turnell-Ritson RC;Hyon DH;White AJP;Ashley AE
• 通讯作者: Ashley AE