Electrochemical hydrogenations

电化学氢化

• 批准号: 1942072
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1942072
• 关键词: Electrochemical; hydrogenations

Reduction chemistry remains a vital and powerful technique throughout academia and industry in the synthesis of complex organic molecules. Moreover, hydrogenation methods should become more important, as society transitions away from the use of highly reduced petroleum in the chemical industries toward the more oxidised biomass, in which reduction methods are necessary to bring it to application. Despite the importance and prevalence of this reaction to organic synthesis, typical strategies often employ the use of expensive transition metal catalysts, such as iridium or rhodium, in combination with pressurised vessels of explosive hydrogen gas, or, in the case of transfer hydrogenation methods are limited in substrate scope.As a possible alternative, we aim to explore the use of electrochemistry and base metal catalysis to develop hydrogenation methods that are more environmentally benign, inexpensive and selective.

还原化学在整个学术界和工业界仍然是合成复杂有机分子的重要和强大的技术。此外，氢化方法应该变得更加重要，因为社会从化学工业中使用高度还原的石油过渡到更氧化的生物质，其中还原方法是必要的。尽管该反应对有机合成的重要性和普遍性，但典型的策略通常采用使用昂贵的过渡金属催化剂，如铱或铑，与爆炸性氢气的加压容器组合，或者在转移氢化方法的情况下，在底物范围内受到限制。我们的目标是探索电化学和贱金属催化的使用，以开发更环保、更便宜和更有选择性的氢化方法。

项目成果

Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates

烯烃的电化学邻位二氟化：可扩展且适用于富电子基质

• DOI: 10.1002/ange.201912119
• 发表时间: 2019
• 期刊: Angewandte Chemie
• 作者: Doobary S