INSTRUMENTAL ANALYSIS

仪器分析

• 批准号: 6431899
• 负责人: George H Weiss
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6431899
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; capillary electrophoresis; clinical biomedical equipment; digital imaging; gel electrophoresis; image processing; nuclear magnetic resonance spectroscopy; ultrasonography; zonal electrophoresis

This project studies several types of instrumentation to understand basic aspects of their operation as required for optimizing their operation. Dr. George Weiss has been working with Drs. Sinisa Pajevic, Marian Bogunya (CIT) and Dr. Peter Basser (NICHD) on determining statistical properties of tract following by Diffusion Tensor Imaging, in particular studying how far, on average it is possible to follow a fiber by this method before it is completely corrupted by random noise. We showed that in the ideal case of a straight fiber one could formulate the problem in terms of a diffusion model with an extrapolated absorbing boundary. The results of analyzing this model was in excellent agreement with simulated data. A paper containing these results has been submitted to Magnetic Resonance in Medicine. A second project concerns the use of single-molecule spectroscopy (SMS) techniques to measure rate constants in chemical reactions. A variety of problems in this area have been explored together with Drs. Marian Bogunya, Alexander Berezhkovskii, and Attila Szabo (NIDDK). An earlier result derived by us gave an exact mathematical solution for calculating rate constants for the ideal isomerization reaction. Further formalism has been developed for analyzing more complicated reactions. We have just begun to study the question of how precise these measurements are.

该项目研究了几种类型的仪器，以了解其操作的基本方面，以优化其操作。 乔治韦斯博士一直在与Sinisa Pajevic博士、Marian Bogunya博士（CIT）和Peter Basser博士（NICHD）合作，确定弥散张量成像跟踪纤维束的统计特性，特别是研究在纤维被随机噪声完全破坏之前，这种方法平均可以跟踪纤维多远。我们表明，在理想的情况下，一个直纤维可以制定的扩散模型与外推吸收边界的问题。模型分析结果与模拟数据吻合较好。包含这些结果的论文已提交给医学磁共振。 第二个项目涉及使用单分子光谱（SMS）技术来测量化学反应的速率常数。与Marian Bogunya、亚历山大Berezhkovskii和Attila Szabo博士（NIDDK）一起探讨了这一领域的各种问题。我们以前的一个结果给出了计算理想异构化反应速率常数的精确数学解。为了分析更复杂的反应，进一步发展了形式主义。我们刚刚开始研究这些测量的精确度问题。