Instrumental Analysis

仪器分析

• 批准号: 6832596
• 负责人: George H Weiss
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6832596
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; diagnosis design /evaluation; digital imaging; image processing; mathematical model; optics; spectrometry

The purpose of this project is to develop theory for the interpretation of biomedical and chemical measurement techniques. At present we are working on optical spectroscopy applied to estimate optical tissue parameters to distinguish between normal and abnormal tissues. The project deals with the theory of optical measurements as used to estimate optical properties of human tissue. This project has generated research on defining the region of tissue visited by laser-generated photons. Since it has been shown that properties of tissue can successfully be found from models based on random walks on discrete lattices, we have identified the region visited by photons with the expected number of distinct sites visited by the random walk conditioned to emerge at an interface, where it can be identified with a light intensity. A physical model has been developed for this process and applied to reflectance and transillumination measurements. With regard to the use of optical techniques for imaging purposes we have proposed a technique for characterizing the region probed by a photon which is ultimately re-emitted by the medium (i.e., tissue). This is based on the observation that tissue can be modeled as a simple cubic lattice. It is possible to calculate the expected number of lattice sites visited by a re-emitted photon. This then provides a parameter related to the region visited by the photon. A more recent project relates to developing theory to treat photon migration in tissues, exemplified by teeth, in which the underlying optical parameters are anisotropic. As a first step we have considered a very specific form of anisotropy which allows two favored directions, but a theory to deal with more general forms of anisotripicity is currently being developed.

该项目的目的是发展生物医学和化学测量技术的解释理论。目前，我们正在研究应用光谱学来估计光学组织参数，以区分正常和异常组织。该项目涉及用于估计人体组织光学特性的光学测量理论。该项目产生了关于定义激光产生的光子所访问的组织区域的研究。由于已经表明，可以成功地从基于离散晶格上的随机游走的模型中找到组织的属性，因此我们已经确定了光子访问的区域，其中随机游走访问的不同位点的预期数量被调节为出现在界面处，在那里它可以用光强度来识别。已经开发了一个物理模型，这个过程中，并应用于反射率和透射测量。关于用于成像目的的光学技术的使用，我们已经提出了一种用于表征由光子探测的区域的技术，该光子最终由介质重新发射（即，组织）。这是基于组织可以被建模为简单立方晶格的观察。可以计算再发射光子所访问的晶格位置的预期数量。然后，这提供了与光子访问的区域相关的参数。最近的一个项目涉及发展理论来治疗组织中的光子迁移，例如牙齿，其中基本的光学参数是各向异性的。作为第一步，我们已经考虑了一种非常特殊的各向异性形式，它允许两个有利的方向，但目前正在开发一种理论来处理更一般形式的各向异性。