Instrumental Analysis

仪器分析

• 批准号: 7145044
• 负责人: George H Weiss
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7145044
• 关键词: mathematical model; optics; technology /technique development

The purpose of this project is to develop theory for the interpretation of biomedical and chemical measurement techniques. At present we are working on optical spectroscopy applied to estimate optical tissue parameters to distinguish between normal and abnormal tissues. The project deals with the theory of optical measurements as used to estimate optical properties of human tissue. The main subject under investigation at present is that of determining the effects of anisotropic optical parameters on measurements made in the time-gated mode, that is, when light intensities induced by a laser source irradiating tissue are measured as a function of time, rather than of the light intensity from a continuous beam measured as a function of the distance between the source and the detector. We have developed a mathematical formalism to solve problems in media whose optical parameters are anisotropic with respect to a slab geometry model, and using this model indicated how to estimate the angles that characterize the anisotropy from measurements of the light intensity as a function of time.

该项目的目的是发展生物医学和化学测量技术的解释理论。目前，我们正在研究应用光谱学来估计光学组织参数，以区分正常和异常组织。该项目涉及用于估计人体组织光学特性的光学测量理论。目前研究的主要课题是确定各向异性光学参数对在时间选通模式下进行的测量的影响，即，当由照射组织的激光源引起的光强度作为时间的函数被测量时，而不是作为源和检测器之间的距离的函数测量的来自连续光束的光强度。我们已经开发了一种数学形式主义来解决介质中的问题，其光学参数是各向异性相对于板几何模型，并使用该模型表示如何估计的角度，从测量的光强度作为时间的函数的特征的各向异性。